Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats

Rationale Sazetidine-A is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. It has been shown in previous studies to significantly reduce nicotine self-administration in rats after acute or repeated injections. However, the effects of continuous chronic infusions of sazeti...

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Veröffentlicht in:	Psychopharmacologia 2012-07, Vol.222 (2), p.269-276
Hauptverfasser:	Johnson, Joshua E., Slade, Susan, Wells, Corinne, Petro, Ann, Sexton, Hannah, Rezvani, Amir H., Brown, Milton L., Paige, Mikell A., McDowell, Brian E., Xiao, Yingxian, Kellar, Kenneth J., Levin, Edward D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Animals Azetidines - administration & dosage Azetidines - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Delivery. Postpartum. Lactation Dose-Response Relationship, Drug Drug self-administration Drug therapy Female Gynecology. Andrology. Obstetrics Male Medical sciences Neurosciences Nicotine Nicotine - administration & dosage Nicotinic Agonists - administration & dosage Nicotinic Agonists - pharmacology Original Investigation Pharmacology/Toxicology Psychiatry Pyridines - administration & dosage Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Rodents Self Administration Sex Factors Smoking Smoking cessation Smoking Cessation - methods
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