An Ultrahigh Affinity d-Peptide Antagonist Of MDM2

The oncoprotein MDM2 negatively regulates the activity and stability of the p53 tumor suppressor and is an important molecular target for anticancer therapy. Aided by mirror image phage display and native chemical ligation, we have previously discovered several proteolysis-resistant duodecimal d-pep...

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Veröffentlicht in:	Journal of medicinal chemistry 2012-07, Vol.55 (13), p.6237-6241
Hauptverfasser:	Zhan, Changyou, Zhao, Le, Wei, Xiaoli, Wu, Xueji, Chen, Xishan, Yuan, Weirong, Lu, Wei-Yue, Pazgier, Marzena, Lu, Wuyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Crystallography, X-Ray Drug Design Humans Inhibitory Concentration 50 Models, Molecular Oligopeptides - chemistry Oligopeptides - pharmacology Proteolysis Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - metabolism Structure-Activity Relationship Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - metabolism
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