Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II

Key points • Rapid exchange of metabolites like glucose and lactate between different cell types is crucial for energy supply to the brain. • Carbonic anhydrase 2 (CAII) enhances lactate transport in mouse cerebellar and cerebral astrocytes. • Enhancement of transport activity is independent of...

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Veröffentlicht in:	The Journal of physiology 2012-05, Vol.590 (10), p.2333-2351
Hauptverfasser:	Stridh, Malin H., Alt, Marco D., Wittmann, Sarah, Heidtmann, Hella, Aggarwal, Mayank, Riederer, Brigitte, Seidler, Ursula, Wennemuth, Gunther, McKenna, Robert, Deitmer, Joachim W., Becker, Holger M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Carbonic Anhydrase II - deficiency Carbonic Anhydrase II - genetics Carbonic Anhydrase II - metabolism Cells, Cultured Cerebellum - metabolism Enzymes Female Lactic Acid - metabolism Metabolites Mice Mice, Knockout Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Neuroscience: Cellular/Molecular Oocytes RNA, Small Interfering - genetics Symporters - genetics Symporters - metabolism Xenopus laevis
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