DNA-polymerase inhibitors. Rifamycin derivatives

Ten new derivatives of the antibiotic rifamycin with variable side chains at position 3 were synthesized. The inhibitory activity of these derivatives against DNA-polymerases isolated from avian myeloblastosie virus, E.coli and calf thy-raus were studied at various conditions. 3-(2,4,6-trinitrophe-n...

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Veröffentlicht in:	Nucleic acids research 1977-03, Vol.4 (3), p.523-538
Hauptverfasser:	Frolova, L.Yu, Meldrays, Ya.A., Kochkina, L.L., Giller, S.A., Eremeyev, A.V., Grayevskaya, N.A., Kisselev, L.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian myeloblastosis virus Avian Myeloblastosis Virus - enzymology Binding Sites Cattle Chemical Phenomena Chemistry DNA Polymerase I - antagonists & inhibitors Escherichia coli Escherichia coli - enzymology Nucleic Acid Synthesis Inhibitors Reverse Transcriptase Inhibitors Rifamycins - pharmacology Species Specificity Structure-Activity Relationship Templates, Genetic Thymus Gland - enzymology
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