CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

When mammalian cells experience radiation insult, DNA replication is stalled to prevent erroneous DNA synthesis. UV-irradiation triggers proteolysis of Mcm10, an essential human replication factor, inhibiting the ongoing replication. Here, we report that Mcm10 associates with E3 ubiquitin ligase com...

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Veröffentlicht in:	Nucleic acids research 2012-08, Vol.40 (15), p.7332-7346
Hauptverfasser:	Kaur, Manpreet, Khan, Md Muntaz, Kar, Ananya, Sharma, Aparna, Saxena, Sandeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Cell Line cullin Cullin Proteins - metabolism DNA biosynthesis DNA Replication DNA-Binding Proteins - metabolism Gene Expression Regulation Genome Integrity, Repair and HeLa Cells Humans Mammalian cells Minichromosome Maintenance Proteins Protein Structure, Tertiary Proteolysis Radiation Replication RING finger proteins Stress Stress, Physiological - genetics Transcription, Genetic Ubiquitin-protein ligase Ubiquitination Ultraviolet Rays
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