Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays
We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analys...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2012-01, Vol.2012 (2012), p.1-6 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6 |
|---|---|
| container_issue | 2012 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2012 |
| creator | De Mello, Marco Túlio Tufik, Sergio Zager, Adriano Taboga, Sebastião Roberto Santos, Fernanda C. Vilamaior, Patricia S. L. Venâncio, Daniel P. Andersen, Monica L. |
| description | We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR. |
| doi_str_mv | 10.1155/2012/285938 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3423984</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1036876780</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-cf2eda3d25166dddfae95dd919b57449087c879e73be296ca4689b3f942191b63</originalsourceid><addsrcrecordid>eNqFkktv1DAUhSMEog9YsQZZYlMBQ_1KYrNAigZokaYCUWAbOfHNxFUmDrbTKv-Cn4xDygjYdGVL_nyuz_FJkicEvyYkTU8pJvSUilQycS85JITgVU5Tcn-_5-wgOfL-CmOSi0w-TA4olTTPiTxMfl52AAN6B4Mz1yoY26OiC-A8-qIC-g59cKpDn531QQVAF9YNre3sdnqFNqC06bcoWHTWqV6PnXKoCM4O7YTeoAJdmDreq-1ganQZRj2htZ31fACNbkxoUWgBnVu3s30cUnivJv8oedCozsPj2_U4-fbh_df1-Wrz6ezjutisai5lWNUNBa2YjkazTGvdKJCp1pLIKs05l1jktcgl5KwCKrNa8UzIijWSUyJJlbHj5O2iO4zVDnS9OC1jDDvlptIqU_570pu23NrrknHKpOBR4ORWwNkfI_hQ7oyvoYtRgB19SVj8EywwZ3ejmGUiz3KBI_r8P_TKji7G85sSHAuSzbNfLtQcsHfQ7N9NcDmXopxLUS6liPSzv63u2T8tiMCLBWhNr9WNuUPt6QJDRKBRe5hnmMeu_QIEscnL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1038408164</pqid></control><display><type>article</type><title>Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>De Mello, Marco Túlio ; Tufik, Sergio ; Zager, Adriano ; Taboga, Sebastião Roberto ; Santos, Fernanda C. ; Vilamaior, Patricia S. L. ; Venâncio, Daniel P. ; Andersen, Monica L.</creator><contributor>Gualillo, Oreste</contributor><creatorcontrib>De Mello, Marco Túlio ; Tufik, Sergio ; Zager, Adriano ; Taboga, Sebastião Roberto ; Santos, Fernanda C. ; Vilamaior, Patricia S. L. ; Venâncio, Daniel P. ; Andersen, Monica L. ; Gualillo, Oreste</creatorcontrib><description>We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2012/285938</identifier><identifier>PMID: 22927719</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Androgens ; Animals ; Atrophy ; Biological Assay ; Corticosterone - blood ; Laboratory animals ; Male ; Prostate - metabolism ; Prostate - pathology ; Rats ; Rats, Wistar ; Reproductive system ; Rodents ; Shift work ; Sleep apnea ; Sleep deprivation ; Sleep Deprivation - blood ; Sleep Deprivation - pathology ; Sleep, REM ; Staining and Labeling ; Testosterone ; Testosterone - blood</subject><ispartof>BioMed research international, 2012-01, Vol.2012 (2012), p.1-6</ispartof><rights>Copyright © 2012 Daniel P. Venâncio et al.</rights><rights>Copyright © 2012 Daniel P. Venâncio et al. Daniel P. Venâncio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2012 Daniel P. Venâncio et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-cf2eda3d25166dddfae95dd919b57449087c879e73be296ca4689b3f942191b63</citedby><cites>FETCH-LOGICAL-c499t-cf2eda3d25166dddfae95dd919b57449087c879e73be296ca4689b3f942191b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423984/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423984/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22927719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gualillo, Oreste</contributor><creatorcontrib>De Mello, Marco Túlio</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Zager, Adriano</creatorcontrib><creatorcontrib>Taboga, Sebastião Roberto</creatorcontrib><creatorcontrib>Santos, Fernanda C.</creatorcontrib><creatorcontrib>Vilamaior, Patricia S. L.</creatorcontrib><creatorcontrib>Venâncio, Daniel P.</creatorcontrib><creatorcontrib>Andersen, Monica L.</creatorcontrib><title>Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.</description><subject>Androgens</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Biological Assay</subject><subject>Corticosterone - blood</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Prostate - metabolism</subject><subject>Prostate - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproductive system</subject><subject>Rodents</subject><subject>Shift work</subject><subject>Sleep apnea</subject><subject>Sleep deprivation</subject><subject>Sleep Deprivation - blood</subject><subject>Sleep Deprivation - pathology</subject><subject>Sleep, REM</subject><subject>Staining and Labeling</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>1110-7243</issn><issn>2314-6133</issn><issn>1110-7251</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkktv1DAUhSMEog9YsQZZYlMBQ_1KYrNAigZokaYCUWAbOfHNxFUmDrbTKv-Cn4xDygjYdGVL_nyuz_FJkicEvyYkTU8pJvSUilQycS85JITgVU5Tcn-_5-wgOfL-CmOSi0w-TA4olTTPiTxMfl52AAN6B4Mz1yoY26OiC-A8-qIC-g59cKpDn531QQVAF9YNre3sdnqFNqC06bcoWHTWqV6PnXKoCM4O7YTeoAJdmDreq-1ganQZRj2htZ31fACNbkxoUWgBnVu3s30cUnivJv8oedCozsPj2_U4-fbh_df1-Wrz6ezjutisai5lWNUNBa2YjkazTGvdKJCp1pLIKs05l1jktcgl5KwCKrNa8UzIijWSUyJJlbHj5O2iO4zVDnS9OC1jDDvlptIqU_570pu23NrrknHKpOBR4ORWwNkfI_hQ7oyvoYtRgB19SVj8EywwZ3ejmGUiz3KBI_r8P_TKji7G85sSHAuSzbNfLtQcsHfQ7N9NcDmXopxLUS6liPSzv63u2T8tiMCLBWhNr9WNuUPt6QJDRKBRe5hnmMeu_QIEscnL</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>De Mello, Marco Túlio</creator><creator>Tufik, Sergio</creator><creator>Zager, Adriano</creator><creator>Taboga, Sebastião Roberto</creator><creator>Santos, Fernanda C.</creator><creator>Vilamaior, Patricia S. L.</creator><creator>Venâncio, Daniel P.</creator><creator>Andersen, Monica L.</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays</title><author>De Mello, Marco Túlio ; Tufik, Sergio ; Zager, Adriano ; Taboga, Sebastião Roberto ; Santos, Fernanda C. ; Vilamaior, Patricia S. L. ; Venâncio, Daniel P. ; Andersen, Monica L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-cf2eda3d25166dddfae95dd919b57449087c879e73be296ca4689b3f942191b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Androgens</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Biological Assay</topic><topic>Corticosterone - blood</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Prostate - metabolism</topic><topic>Prostate - pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproductive system</topic><topic>Rodents</topic><topic>Shift work</topic><topic>Sleep apnea</topic><topic>Sleep deprivation</topic><topic>Sleep Deprivation - blood</topic><topic>Sleep Deprivation - pathology</topic><topic>Sleep, REM</topic><topic>Staining and Labeling</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Mello, Marco Túlio</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Zager, Adriano</creatorcontrib><creatorcontrib>Taboga, Sebastião Roberto</creatorcontrib><creatorcontrib>Santos, Fernanda C.</creatorcontrib><creatorcontrib>Vilamaior, Patricia S. L.</creatorcontrib><creatorcontrib>Venâncio, Daniel P.</creatorcontrib><creatorcontrib>Andersen, Monica L.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Mello, Marco Túlio</au><au>Tufik, Sergio</au><au>Zager, Adriano</au><au>Taboga, Sebastião Roberto</au><au>Santos, Fernanda C.</au><au>Vilamaior, Patricia S. L.</au><au>Venâncio, Daniel P.</au><au>Andersen, Monica L.</au><au>Gualillo, Oreste</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays</atitle><jtitle>BioMed research international</jtitle><addtitle>J Biomed Biotechnol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1110-7243</issn><issn>2314-6133</issn><eissn>1110-7251</eissn><eissn>2314-6141</eissn><abstract>We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>22927719</pmid><doi>10.1155/2012/285938</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1110-7243 |
| ispartof | BioMed research international, 2012-01, Vol.2012 (2012), p.1-6 |
| issn | 1110-7243 2314-6133 1110-7251 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3423984 |
| source | MEDLINE; PubMed Central Open Access; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Androgens Animals Atrophy Biological Assay Corticosterone - blood Laboratory animals Male Prostate - metabolism Prostate - pathology Rats Rats, Wistar Reproductive system Rodents Shift work Sleep apnea Sleep deprivation Sleep Deprivation - blood Sleep Deprivation - pathology Sleep, REM Staining and Labeling Testosterone Testosterone - blood |
| title | Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy : A Microscopic Study Contrasted with the Hormonal Assays |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T15%3A40%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sleep%20Deprivation%20Alters%20Rat%20Ventral%20Prostate%20Morphology,%20Leading%20to%20Glandular%20Atrophy%20:%20A%20Microscopic%20Study%20Contrasted%20with%20the%20Hormonal%20Assays&rft.jtitle=BioMed%20research%20international&rft.au=De%20Mello,%20Marco%20T%C3%BAlio&rft.date=2012-01-01&rft.volume=2012&rft.issue=2012&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=1110-7243&rft.eissn=1110-7251&rft_id=info:doi/10.1155/2012/285938&rft_dat=%3Cproquest_pubme%3E1036876780%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1038408164&rft_id=info:pmid/22927719&rfr_iscdi=true |