RNA Interference Trigger Variants: Getting the Most Out of RNA for RNA Interference-Based Therapeutics

The manifestation of RNA interference (RNAi)-based therapeutics lies in safe and successful delivery of small interfering RNAs (siRNAs), the molecular entity that triggers and guides sequence-specific degradation of target mRNAs. Optimizing the chemistry and structure of siRNAs to achieve maximum ef...

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Veröffentlicht in:	Nucleic acid therapeutics 2012-06, Vol.22 (3), p.139-146
Hauptverfasser:	Snead, Nicholas M., Rossi, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical synthesis Clinical Trials as Topic Drug development Humans mRNA Proteins Review Reviews Ribonucleic acid RNA RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - therapeutic use RNA-mediated interference siRNA Transfer RNA
Online-Zugang:	Volltext
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