Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice

Nrf2 is an essential transcription factor for protection against oxidant disorders. However, its role in organ development and neonatal disease has received little attention. Therapeutically administered oxygen has been considered to contribute to bronchopulmonary dysplasia (BPD) in prematurity. The...

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Veröffentlicht in:	Antioxidants & redox signaling 2012-10, Vol.17 (8), p.1066-1082
Hauptverfasser:	Cho, Hye-Youn, van Houten, Bennett, Wang, Xuting, Miller-DeGraff, Laura, Fostel, Jennifer, Gladwell, Wesley, Perrow, Ligon, Panduri, Vijayalakshmi, Kobzik, Lester, Yamamoto, Masayuki, Bell, Douglas A, Kleeberger, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Gene Deletion Glutathione Peroxidase - deficiency Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Hyperoxia - metabolism Lung - embryology Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Original Research Communications Oxidative Stress Phenotype
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