Isolation of a Δ5 Desaturase Gene from Euglena gracilis and Functional Dissection of Its HPGG and HDASH Motifs

Delta (Δ) 5 desaturase is a key enzyme for the biosynthesis of health-beneficial long chain polyunsaturated fatty acids such as arachidonic acid (ARA, C20:4n-6), eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3) via the “desaturation and elongation” pathways. A full length Δ5 desa...

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Veröffentlicht in:	Lipids 2012-09, Vol.47 (9), p.913-926
Hauptverfasser:	Pollak, Dana Walters, Bostick, Michael W., Yoon, Hyeryoung, Wang, Jamie, Hollerbach, Dieter H., He, Hongxian, Damude, Howard G., Zhang, Hongxiang, Yadav, Narendra S., Hong, Seung-Pyo, Sharpe, Pamela, Xue, Zhixiong, Zhu, Quinn
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Biomedical and Life Sciences Double mutant Euglena gracilis - enzymology Euglena gracilis - genetics Fatty acid biosynthesis Fatty Acid Desaturases - chemistry Fatty Acid Desaturases - genetics Fatty Acid Desaturases - metabolism HDASH motif HPGG motif Life Sciences Lipidology Medical Biochemistry Medicinal Chemistry Microbial Genetics and Genomics Models, Biological Molecular Sequence Data Neurochemistry Nutrition Original Original Article Sequence Alignment Yarrowia lipolytica Δ5 desaturase
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