A comparison of the combined ultrasound of the mediastinum by use of a single ultrasound bronchoscope versus ultrasound bronchoscope plus ultrasound gastroscope in lung cancer staging: a prospective trial
OBJECTIVES The aim of the study was to compare diagnostic utility of combined (i.e. transbronchial and transoesophageal) ultrasound imaging with needle biopsy of the mediastinum in lung cancer (LC) staging, (a) by use of a single ultrasound bronchoscope (CUSb) and (b) by using two scopes (CUS). METH...
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| Veröffentlicht in: | Interactive cardiovascular and thoracic surgery 2012-09, Vol.15 (3), p.442-446 |
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| container_title | Interactive cardiovascular and thoracic surgery |
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| creator | Szlubowski, Artur Soja, Jerzy Koco, Piotr Talar, Piotr Czajkowski, Wojciech Rudnicka-Sosin, Lucyna miel, Adam Ku d a, Jaros aw |
| description | OBJECTIVES
The aim of the study was to compare diagnostic utility of combined (i.e. transbronchial and transoesophageal) ultrasound imaging with needle biopsy of the mediastinum in lung cancer (LC) staging, (a) by use of a single ultrasound bronchoscope (CUSb) and (b) by using two scopes (CUS).
METHODS
In consecutive LC patients, clinical stage IA-IIIB the CUS or CUSb was performed under mild sedation and, if negative, underwent lung resection with confirmatory systematic lymph node dissection.
RESULTS
From 214 LC patients, 110 underwent CUS and 104 underwent CUSb (618 biopsies); both revealed metastases in 50% of cases. There was 'minimal N2' in 11 of 14 false negative patients. Diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of CUS was 91.7%, 98%, 94.6%, 98.2% and 90.7% respectively and of CUSb was 85%, 93.2%, 88.5%, 94.4%, 82%, respectively with no significant difference in yield of CUS vs CUSb (P = 0.255 and P = 0.192). The mean time of CUS (25 ± 4.4 min) was significantly longer as compared to CUSb (14.9 ± 2.3 min) (P < 0.001). No severe complications of either method were observed.
CONCLUSIONS
The combined ultrasound imaging of the mediastinum by use of CUSb is significantly less time-consuming and equally as effective and safe as the use of CUS for LC staging. |
| doi_str_mv | 10.1093/icvts/ivs161 |
| format | Article |
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The aim of the study was to compare diagnostic utility of combined (i.e. transbronchial and transoesophageal) ultrasound imaging with needle biopsy of the mediastinum in lung cancer (LC) staging, (a) by use of a single ultrasound bronchoscope (CUSb) and (b) by using two scopes (CUS).
METHODS
In consecutive LC patients, clinical stage IA-IIIB the CUS or CUSb was performed under mild sedation and, if negative, underwent lung resection with confirmatory systematic lymph node dissection.
RESULTS
From 214 LC patients, 110 underwent CUS and 104 underwent CUSb (618 biopsies); both revealed metastases in 50% of cases. There was 'minimal N2' in 11 of 14 false negative patients. Diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of CUS was 91.7%, 98%, 94.6%, 98.2% and 90.7% respectively and of CUSb was 85%, 93.2%, 88.5%, 94.4%, 82%, respectively with no significant difference in yield of CUS vs CUSb (P = 0.255 and P = 0.192). The mean time of CUS (25 ± 4.4 min) was significantly longer as compared to CUSb (14.9 ± 2.3 min) (P < 0.001). No severe complications of either method were observed.
CONCLUSIONS
The combined ultrasound imaging of the mediastinum by use of CUSb is significantly less time-consuming and equally as effective and safe as the use of CUS for LC staging.</description><identifier>ISSN: 1569-9293</identifier><identifier>EISSN: 1569-9285</identifier><identifier>DOI: 10.1093/icvts/ivs161</identifier><identifier>PMID: 22623626</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Biopsy, Needle - methods ; Bronchoscopes ; Endosonography - instrumentation ; Equipment Design ; Female ; Follow-Up Studies ; Gastroscopes ; Humans ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - pathology ; Male ; Mediastinum - diagnostic imaging ; Mediastinum - pathology ; Middle Aged ; Neoplasm Staging - methods ; Original ; Prospective Studies ; Reproducibility of Results</subject><ispartof>Interactive cardiovascular and thoracic surgery, 2012-09, Vol.15 (3), p.442-446</ispartof><rights>The Author 2012. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-f3bce935b444223e83e28856ee88b8f05a596ed0b91b1418baae324b038033e93</citedby><cites>FETCH-LOGICAL-c482t-f3bce935b444223e83e28856ee88b8f05a596ed0b91b1418baae324b038033e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422922/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422922/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1604,27924,27925,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/icvts/ivs161$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22623626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szlubowski, Artur</creatorcontrib><creatorcontrib>Soja, Jerzy</creatorcontrib><creatorcontrib>Koco, Piotr</creatorcontrib><creatorcontrib>Talar, Piotr</creatorcontrib><creatorcontrib>Czajkowski, Wojciech</creatorcontrib><creatorcontrib>Rudnicka-Sosin, Lucyna</creatorcontrib><creatorcontrib>miel, Adam</creatorcontrib><creatorcontrib>Ku d a, Jaros aw</creatorcontrib><title>A comparison of the combined ultrasound of the mediastinum by use of a single ultrasound bronchoscope versus ultrasound bronchoscope plus ultrasound gastroscope in lung cancer staging: a prospective trial</title><title>Interactive cardiovascular and thoracic surgery</title><addtitle>Interact Cardiovasc Thorac Surg</addtitle><description>OBJECTIVES
The aim of the study was to compare diagnostic utility of combined (i.e. transbronchial and transoesophageal) ultrasound imaging with needle biopsy of the mediastinum in lung cancer (LC) staging, (a) by use of a single ultrasound bronchoscope (CUSb) and (b) by using two scopes (CUS).
METHODS
In consecutive LC patients, clinical stage IA-IIIB the CUS or CUSb was performed under mild sedation and, if negative, underwent lung resection with confirmatory systematic lymph node dissection.
RESULTS
From 214 LC patients, 110 underwent CUS and 104 underwent CUSb (618 biopsies); both revealed metastases in 50% of cases. There was 'minimal N2' in 11 of 14 false negative patients. Diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of CUS was 91.7%, 98%, 94.6%, 98.2% and 90.7% respectively and of CUSb was 85%, 93.2%, 88.5%, 94.4%, 82%, respectively with no significant difference in yield of CUS vs CUSb (P = 0.255 and P = 0.192). The mean time of CUS (25 ± 4.4 min) was significantly longer as compared to CUSb (14.9 ± 2.3 min) (P < 0.001). No severe complications of either method were observed.
CONCLUSIONS
The combined ultrasound imaging of the mediastinum by use of CUSb is significantly less time-consuming and equally as effective and safe as the use of CUS for LC staging.</description><subject>Biopsy, Needle - methods</subject><subject>Bronchoscopes</subject><subject>Endosonography - instrumentation</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroscopes</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Mediastinum - diagnostic imaging</subject><subject>Mediastinum - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>Original</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><issn>1569-9293</issn><issn>1569-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1vFCEYxonR2Lp682y46cG1fMxMwYNJ0_jRpImX9kyAfWcWw8AIwyT9H_2jZN3tpj3YE4Tn977PCzwIvaXkEyWSnzm7zPnMLZl29Bk6pW0n15KJ9vlxL_kJepXzL0KoJJy8RCeMdYx3rDtFfy6wjeOkk8sx4NjjeQu7E-MCbHDxc9I5lrC5l0bYOJ1nF8qIzR0uGXaKxtmFwcPDApNisNuYbZwAL5Byyf-VJ_9YHKpFOmguYF_CgK0OFhLOsx6q1-fqOVVkAju7BfCcnPav0Yte-wxvDusK3X77enP5Y3398_vV5cX12jaCzeueGwuSt6ZpGsY4CA5MiLYDEMKInrS6lR1siJHU0IYKozVw1hjCBeG8Vq7Ql33fqZj6IBZCndyrKblRpzsVtVOPleC2aoiL4tVPVssV-nBokOLvAnlWo8sWvNcBYsmKEt50rTg_JxX9uEdtvW1O0B9tKFG7AKh_AVD7AFT83cPRjvD9j1fg_R6IZXq61V_n4cOq</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Szlubowski, Artur</creator><creator>Soja, Jerzy</creator><creator>Koco, Piotr</creator><creator>Talar, Piotr</creator><creator>Czajkowski, Wojciech</creator><creator>Rudnicka-Sosin, Lucyna</creator><creator>miel, Adam</creator><creator>Ku d a, Jaros aw</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120901</creationdate><title>A comparison of the combined ultrasound of the mediastinum by use of a single ultrasound bronchoscope versus ultrasound bronchoscope plus ultrasound gastroscope in lung cancer staging: a prospective trial</title><author>Szlubowski, Artur ; Soja, Jerzy ; Koco, Piotr ; Talar, Piotr ; Czajkowski, Wojciech ; Rudnicka-Sosin, Lucyna ; miel, Adam ; Ku d a, Jaros aw</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-f3bce935b444223e83e28856ee88b8f05a596ed0b91b1418baae324b038033e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biopsy, Needle - methods</topic><topic>Bronchoscopes</topic><topic>Endosonography - instrumentation</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroscopes</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Mediastinum - diagnostic imaging</topic><topic>Mediastinum - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>Original</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szlubowski, Artur</creatorcontrib><creatorcontrib>Soja, Jerzy</creatorcontrib><creatorcontrib>Koco, Piotr</creatorcontrib><creatorcontrib>Talar, Piotr</creatorcontrib><creatorcontrib>Czajkowski, Wojciech</creatorcontrib><creatorcontrib>Rudnicka-Sosin, Lucyna</creatorcontrib><creatorcontrib>miel, Adam</creatorcontrib><creatorcontrib>Ku d a, Jaros aw</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Interactive cardiovascular and thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Szlubowski, Artur</au><au>Soja, Jerzy</au><au>Koco, Piotr</au><au>Talar, Piotr</au><au>Czajkowski, Wojciech</au><au>Rudnicka-Sosin, Lucyna</au><au>miel, Adam</au><au>Ku d a, Jaros aw</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the combined ultrasound of the mediastinum by use of a single ultrasound bronchoscope versus ultrasound bronchoscope plus ultrasound gastroscope in lung cancer staging: a prospective trial</atitle><jtitle>Interactive cardiovascular and thoracic surgery</jtitle><addtitle>Interact Cardiovasc Thorac Surg</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>15</volume><issue>3</issue><spage>442</spage><epage>446</epage><pages>442-446</pages><issn>1569-9293</issn><eissn>1569-9285</eissn><abstract>OBJECTIVES
The aim of the study was to compare diagnostic utility of combined (i.e. transbronchial and transoesophageal) ultrasound imaging with needle biopsy of the mediastinum in lung cancer (LC) staging, (a) by use of a single ultrasound bronchoscope (CUSb) and (b) by using two scopes (CUS).
METHODS
In consecutive LC patients, clinical stage IA-IIIB the CUS or CUSb was performed under mild sedation and, if negative, underwent lung resection with confirmatory systematic lymph node dissection.
RESULTS
From 214 LC patients, 110 underwent CUS and 104 underwent CUSb (618 biopsies); both revealed metastases in 50% of cases. There was 'minimal N2' in 11 of 14 false negative patients. Diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of CUS was 91.7%, 98%, 94.6%, 98.2% and 90.7% respectively and of CUSb was 85%, 93.2%, 88.5%, 94.4%, 82%, respectively with no significant difference in yield of CUS vs CUSb (P = 0.255 and P = 0.192). The mean time of CUS (25 ± 4.4 min) was significantly longer as compared to CUSb (14.9 ± 2.3 min) (P < 0.001). No severe complications of either method were observed.
CONCLUSIONS
The combined ultrasound imaging of the mediastinum by use of CUSb is significantly less time-consuming and equally as effective and safe as the use of CUS for LC staging.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>22623626</pmid><doi>10.1093/icvts/ivs161</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Interactive cardiovascular and thoracic surgery, 2012-09, Vol.15 (3), p.442-446 |
| issn | 1569-9293 1569-9285 |
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| source | Access via Oxford University Press (Open Access Collection) |
| subjects | Biopsy, Needle - methods Bronchoscopes Endosonography - instrumentation Equipment Design Female Follow-Up Studies Gastroscopes Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Male Mediastinum - diagnostic imaging Mediastinum - pathology Middle Aged Neoplasm Staging - methods Original Prospective Studies Reproducibility of Results |
| title | A comparison of the combined ultrasound of the mediastinum by use of a single ultrasound bronchoscope versus ultrasound bronchoscope plus ultrasound gastroscope in lung cancer staging: a prospective trial |
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