Three-dimensional RNA structure refinement by hydroxyl radical probing

Hydroxyl radical probing measurements of large RNA molecules drive molecular dynamics simulations to generate three-dimensional structural models. Molecular modeling guided by experimentally derived structural information is an attractive approach for three-dimensional structure determination of com...

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Veröffentlicht in:	Nature methods 2012-06, Vol.9 (6), p.603-608
Hauptverfasser:	Ding, Feng, Lavender, Christopher A, Weeks, Kevin M, Dokholyan, Nikolay V
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2397 631/45/500 631/45/535 Analysis Base Pairing Base Sequence Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Hydroxides Hydroxyl Radical - chemistry Hydroxyl radicals Investigations Life Sciences Models, Molecular Molecular biology Molecular Dynamics Simulation Molecular structure Nucleic Acid Conformation Nucleotides Physiological aspects Proteomics Ribonucleic acid RNA RNA - chemistry RNA - ultrastructure RNA, Transfer - chemistry Software Solvents Structure
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