TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2012-09, Vol.56 (9), p.4676-4684
Hauptverfasser:	DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - pharmacology Biological and medical sciences Cell Line Cloning, Molecular Drug Combinations Drug Synergism Enzyme Inhibitors Enzyme Inhibitors - pharmacology Escherichia coli - genetics Genes, Reporter Hepacivirus Hepacivirus - drug effects Hepacivirus - enzymology Hepacivirus - genetics Hepacivirus - growth & development Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Heterocyclic Compounds, 4 or More Rings Heterocyclic Compounds, 4 or More Rings - pharmacology Human viral diseases Humans Infectious diseases Medical sciences Pharmacology. Drug treatments Plasmids Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - metabolism RNA Replicase RNA-Dependent RNA Polymerase - antagonists & inhibitors RNA-Dependent RNA Polymerase - metabolism Sulfonamides Sulfonamides - pharmacology Transfection Viral diseases Viral hepatitis Viral Nonstructural Proteins Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - metabolism Virus Replication - drug effects
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