TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2012-09, Vol.56 (9), p.4676-4684 |
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| creator | DEVOGELAERE, Benoit BERKE, Jan Martin LENZ, Oliver CUMMINGS, Maxwell D CLAYTON, Reginald F VENDEVILLE, Sandrine RABOISSON, Pierre SIMMEN, Kenneth A FANNING, Gregory C LIN, Tse-I VIJGEN, Leen DEHERTOGH, Pascale FRANSEN, Els CLEIREN, Erna VAN DER HELM, Liesbet NYANGUILE, Origène TAHRI, Abdellah AMSSOMS, Katie |
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| doi_str_mv | 10.1128/AAC.00245-12 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00245-12</identifier><identifier>PMID: 22710121</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Cell Line ; Cloning, Molecular ; Drug Combinations ; Drug Synergism ; Enzyme Inhibitors ; Enzyme Inhibitors - pharmacology ; Escherichia coli - genetics ; Genes, Reporter ; Hepacivirus ; Hepacivirus - drug effects ; Hepacivirus - enzymology ; Hepacivirus - genetics ; Hepacivirus - growth & development ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - virology ; Heterocyclic Compounds, 4 or More Rings ; Heterocyclic Compounds, 4 or More Rings - pharmacology ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Pharmacology. Drug treatments ; Plasmids ; Recombinant Proteins - antagonists & inhibitors ; Recombinant Proteins - metabolism ; RNA Replicase ; RNA-Dependent RNA Polymerase - antagonists & inhibitors ; RNA-Dependent RNA Polymerase - metabolism ; Sulfonamides ; Sulfonamides - pharmacology ; Transfection ; Viral diseases ; Viral hepatitis ; Viral Nonstructural Proteins ; Viral Nonstructural Proteins - antagonists & inhibitors ; Viral Nonstructural Proteins - metabolism ; Virus Replication - drug effects</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4676-4684</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2012, American Society for Microbiology. All Rights Reserved. 2012 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a474t-f7919895fd48b21e2c5445804ed33c637383ac778b3dacc88b83ebcce9b639323</citedby><cites>FETCH-LOGICAL-a474t-f7919895fd48b21e2c5445804ed33c637383ac778b3dacc88b83ebcce9b639323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421868/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421868/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26304170$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22710121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEVOGELAERE, Benoit</creatorcontrib><creatorcontrib>BERKE, Jan Martin</creatorcontrib><creatorcontrib>LENZ, Oliver</creatorcontrib><creatorcontrib>CUMMINGS, Maxwell D</creatorcontrib><creatorcontrib>CLAYTON, Reginald F</creatorcontrib><creatorcontrib>VENDEVILLE, Sandrine</creatorcontrib><creatorcontrib>RABOISSON, Pierre</creatorcontrib><creatorcontrib>SIMMEN, Kenneth A</creatorcontrib><creatorcontrib>FANNING, Gregory C</creatorcontrib><creatorcontrib>LIN, Tse-I</creatorcontrib><creatorcontrib>VIJGEN, Leen</creatorcontrib><creatorcontrib>DEHERTOGH, Pascale</creatorcontrib><creatorcontrib>FRANSEN, Els</creatorcontrib><creatorcontrib>CLEIREN, Erna</creatorcontrib><creatorcontrib>VAN DER HELM, Liesbet</creatorcontrib><creatorcontrib>NYANGUILE, Origène</creatorcontrib><creatorcontrib>TAHRI, Abdellah</creatorcontrib><creatorcontrib>AMSSOMS, Katie</creatorcontrib><title>TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Antibiotics. Antiinfectious agents. 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Drug treatments</topic><topic>Plasmids</topic><topic>Recombinant Proteins - antagonists & inhibitors</topic><topic>Recombinant Proteins - metabolism</topic><topic>RNA Replicase</topic><topic>RNA-Dependent RNA Polymerase - antagonists & inhibitors</topic><topic>RNA-Dependent RNA Polymerase - metabolism</topic><topic>Sulfonamides</topic><topic>Sulfonamides - pharmacology</topic><topic>Transfection</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral Nonstructural Proteins</topic><topic>Viral Nonstructural Proteins - antagonists & inhibitors</topic><topic>Viral Nonstructural Proteins - metabolism</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEVOGELAERE, Benoit</creatorcontrib><creatorcontrib>BERKE, Jan Martin</creatorcontrib><creatorcontrib>LENZ, Oliver</creatorcontrib><creatorcontrib>CUMMINGS, Maxwell D</creatorcontrib><creatorcontrib>CLAYTON, Reginald F</creatorcontrib><creatorcontrib>VENDEVILLE, Sandrine</creatorcontrib><creatorcontrib>RABOISSON, Pierre</creatorcontrib><creatorcontrib>SIMMEN, Kenneth A</creatorcontrib><creatorcontrib>FANNING, Gregory C</creatorcontrib><creatorcontrib>LIN, Tse-I</creatorcontrib><creatorcontrib>VIJGEN, Leen</creatorcontrib><creatorcontrib>DEHERTOGH, Pascale</creatorcontrib><creatorcontrib>FRANSEN, Els</creatorcontrib><creatorcontrib>CLEIREN, Erna</creatorcontrib><creatorcontrib>VAN DER HELM, Liesbet</creatorcontrib><creatorcontrib>NYANGUILE, Origène</creatorcontrib><creatorcontrib>TAHRI, Abdellah</creatorcontrib><creatorcontrib>AMSSOMS, Katie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial Agents and Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEVOGELAERE, Benoit</au><au>BERKE, Jan Martin</au><au>LENZ, Oliver</au><au>CUMMINGS, Maxwell D</au><au>CLAYTON, Reginald F</au><au>VENDEVILLE, Sandrine</au><au>RABOISSON, Pierre</au><au>SIMMEN, Kenneth A</au><au>FANNING, Gregory C</au><au>LIN, Tse-I</au><au>VIJGEN, Leen</au><au>DEHERTOGH, Pascale</au><au>FRANSEN, Els</au><au>CLEIREN, Erna</au><au>VAN DER HELM, Liesbet</au><au>NYANGUILE, Origène</au><au>TAHRI, Abdellah</au><au>AMSSOMS, Katie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage</atitle><jtitle>Antimicrobial Agents and Chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>56</volume><issue>9</issue><spage>4676</spage><epage>4684</epage><pages>4676-4684</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Classifications
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>22710121</pmid><doi>10.1128/AAC.00245-12</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4676-4684 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3421868 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - pharmacology Biological and medical sciences Cell Line Cloning, Molecular Drug Combinations Drug Synergism Enzyme Inhibitors Enzyme Inhibitors - pharmacology Escherichia coli - genetics Genes, Reporter Hepacivirus Hepacivirus - drug effects Hepacivirus - enzymology Hepacivirus - genetics Hepacivirus - growth & development Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Heterocyclic Compounds, 4 or More Rings Heterocyclic Compounds, 4 or More Rings - pharmacology Human viral diseases Humans Infectious diseases Medical sciences Pharmacology. Drug treatments Plasmids Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - metabolism RNA Replicase RNA-Dependent RNA Polymerase - antagonists & inhibitors RNA-Dependent RNA Polymerase - metabolism Sulfonamides Sulfonamides - pharmacology Transfection Viral diseases Viral hepatitis Viral Nonstructural Proteins Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - metabolism Virus Replication - drug effects |
| title | TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage |
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