The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk

► Tamoxifen increased the total and carcinogenic estrogen metabolites. ► Tamoxifen reduced antiestrogenic and anticarcinogenic estrogen metabolites. ► Tamoxifen increased the formation of estrogen-DNA adducts. ► Tamoxifen altered expression of estrogen metabolizing genes. ► Raloxifene slightly affec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2011-09, Vol.126 (3), p.78-86
Hauptverfasser:	Williams-Brown, Marian Y., Salih, Sana M., Xu, Xia, Veenstra, Timothy D., Saeed, Muhammad, Theiler, Shaleen K., Diaz-Arrastia, Concepcion R., Salama, Salama A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma - chemically induced Carcinoma - etiology Cells, Cultured DNA Adducts - metabolism Dose-Response Relationship, Drug Drug Combinations Endometrial cancer Endometrial Neoplasms - chemically induced Endometrial Neoplasms - etiology Estradiol - metabolism Estradiol - pharmacology Estrogen Antagonists - adverse effects Estrogen Antagonists - pharmacology Estrogen metabolism Estrogens - metabolism Female Female genital diseases Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Medical sciences Metabolic Networks and Pathways - drug effects Raloxifene Raloxifene Hydrochloride - adverse effects Raloxifene Hydrochloride - pharmacology Risk Factors Selective Estrogen Receptor Modulators - adverse effects Selective Estrogen Receptor Modulators - pharmacology Tamoxifen Tamoxifen - adverse effects Tamoxifen - pharmacology Tumors Vertebrates: endocrinology Vertebrates: reproduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!