Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells

The polyanionic nature of oligonucleotides and their enzymatic degradation present challenges for the use of siRNA in research and therapy; among the most notable of these is clinically relevant delivery into cells. To address this problem, we designed and synthesized the first members of a new clas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-08, Vol.109 (33), p.13171-13176
Hauptverfasser:	Geihe, Erika I, Cooley, Christina B, Simon, Jeff R, Kiesewetter, Matthew K, Edward, Justin A, Hickerson, Robyn P, Kaspar, Roger L, Hedrick, James L, Waymouth, Robert M, Wender, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	biodegradability Biodegradation Biological Sciences Biological Transport - drug effects Carbonates Carbonates - chemical synthesis Carbonates - chemistry Carbonates - toxicity Cell Death - drug effects Cell membranes cell-free protein synthesis Cells Cells, Cultured diagnostic techniques Enzymes Flow Cytometry Fluorescence Gene Transfer Techniques Genes, Reporter - genetics Green Fluorescent Proteins - metabolism Guanidine - chemical synthesis Guanidine - chemistry Guanidine - toxicity Humans image analysis Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Light Lipids Lycopersicon esculentum - metabolism Medical treatment Microscopy, Fluorescence Monomers oligomerization Oligomers oligonucleotides Physical Sciences Protein synthesis Ribonucleic acid RNA RNA, Small Interfering - metabolism RNA, Small Interfering - toxicity Scattering, Radiation Small interfering RNA Teeth therapeutics transporters
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