Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane

In vivo recycling of nitrate (NO ₃⁻) and nitrite (NO ₂⁻) is an important alternative pathway for the generation of nitric oxide (NO) and maintenance of systemic nitrate–nitrite–NO balance. More than 25% of the circulating NO ₃⁻ is actively removed and secreted by salivary glands. Oral commensal bact...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-08, Vol.109 (33), p.13434-13439
Hauptverfasser:	Qin, Lizheng, Liu, Xibao, Sun, Qifei, Fan, Zhipeng, Xia, Dengsheng, Ding, Gang, Ong, Hwei Ling, Adams, David, Gahl, William A, Zheng, Changyu, Qi, Senrong, Jin, Luyuan, Zhang, Chunmei, Gu, Liankun, He, Junqi, Deng, Dajun, Ambudkar, Indu S, Wang, Songlin
Format:	Artikel
Sprache:	eng
Schlagworte:	acidification Acids - metabolism Acinar cells Adenoviridae - metabolism Animals Anion Transport Proteins - metabolism Anions bacteria Biological Sciences Biological Transport blood serum Body fluids bromine Cell Membrane - metabolism Cell membranes diet Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Gene expression Hogs homeostasis Human umbilical vein endothelial cells Intracellular Space - metabolism Membranes mutants Mutation Mutation - genetics N-Acetylneuraminic Acid - metabolism Nitrates Nitrates - metabolism Nitric oxide Nitrites Organic Anion Transporters - genetics Organic Anion Transporters - metabolism patients Physiology plasma membrane Protons Saliva Salivary glands secretion Sialic acid storage disease Sialic Acid Storage Disease - metabolism sialic acids Submandibular Gland - cytology Submandibular Gland - secretion Sus scrofa swine symporters Symporters - genetics Symporters - metabolism
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