The determinants of granulocyte yield in 1198 granulocyte concentrates collected from unrelated volunteer donors mobilized with dexamethasone and granulocyte-colony-stimulating factor: a 13-year experience

BACKGROUND: The combination of granulocyte–colony‐stimulating factor (G‐CSF [filgrastim]) and dexamethasone (G‐CSF/dex) is an effective granulocyte mobilization regimen, but the variables that affect donor neutrophil response and granulocyte collection yield are not well characterized. STUDY DESIGN...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2009-03, Vol.49 (3), p.421-426
Hauptverfasser:	Quillen, Karen, Yau, Yu Ying, Leitman, Susan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Donors Blood Platelets - cytology Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Cell Separation - methods Dexamethasone - pharmacology Female Granulocyte Colony-Stimulating Factor - pharmacology Granulocytes - cytology Granulocytes - drug effects Humans Leukocyte Count Male Medical sciences Middle Aged Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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