Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer

Background: MicroRNA (miRNA)-126 ( miR-126 ) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 ( EGFL7 ). However, the role of miR-126 in cancer is controversial. Methods: We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells...

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Veröffentlicht in:	British journal of cancer 2012-08, Vol.107 (4), p.700-706
Hauptverfasser:	Sasahira, T, Kurihara, M, Bhawal, U K, Ueda, N, Shimomoto, T, Yamamoto, K, Kirita, T, Kuniyasu, H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/67/2328 631/67/68 692/699/67/1536/1665 Aged Aged, 80 and over Angiogenesis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - genetics Cell Line, Tumor Cells Disease-Free Survival DNA methylation Down-Regulation Drug Resistance Endothelial Growth Factors - genetics Epidemiology Epidermal growth factor Female Humans Kinases Lymphangiogenesis - genetics Lymphatic system Male Medical prognosis Medical research Metastasis MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism Middle Aged Molecular Diagnostics Molecular Medicine Mouth Neoplasms - genetics Neovascularization, Pathologic - genetics Oncology Oral cancer Prenatal development Transcriptional Activation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics
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