$Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer$

Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer

Background: Determining the maximum tolerated dose (MTD) and the dose-limiting toxicity (DLT) of sorafenib (S) plus imatinib (IM) in castration-resistant prostate cancer (CRPC) patients. Methods: Refractory CRPC patients were enrolled onto this 3+3 dose escalation designed study. Imatinib pharmacoki...

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Veröffentlicht in:	British journal of cancer 2012-08, Vol.107 (4), p.592-597
Hauptverfasser:	Nabhan, C, Villines, D, Valdez, T V, Tolzien, K, Lestingi, T M, Bitran, J D, Christner, S M, Egorin, M J, Beumer, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/436/108 692/699/67/589/466 692/700/565/1436/1437 Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Benzamides Benzenesulfonates - administration & dosage Biological and medical sciences Biomedical and Life Sciences Biomedicine Bisphosphonates Cancer Research Cancer therapies Castration Chemotherapy Clinical Study Cytotoxicity Drug Administration Schedule Drug dosages Drug Resistance Epidemiology Hematology Humans Imatinib Mesylate Male Maximum Tolerated Dose Medical research Medical sciences Medicine Metastasis Middle Aged Molecular Medicine Nephrology. Urinary tract diseases Niacinamide - analogs & derivatives Oncology Phenylurea Compounds Piperazines - administration & dosage Piperazines - pharmacokinetics Prostate cancer Prostatic Neoplasms - drug therapy Pyridines - administration & dosage Pyrimidines - administration & dosage Pyrimidines - pharmacokinetics Retreatment Treatment Failure Tumors Tumors of the urinary system Urinary tract. Prostate gland
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