Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies

Background: Despite focused research in conventional therapies and considerable advances in the understanding of the molecular carcinogenesis of head and neck squamous cell carcinoma (HNSCC), the 5-year survival rate for patients with advanced disease remains ∼15–20%. The major causes of HNSCC-relat...

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Veröffentlicht in:	British journal of cancer 2012-08, Vol.107 (4), p.707-712
Hauptverfasser:	St John, M A, Wang, G, Luo, J, Dohadwala, M, Hu, D, Lin, Y, Dennis, M, Lee, J M, Elashoff, D, Lawhon, T, Zaknoen, S L, Burrows, F J, Dubinett, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/602 692/699/67/1536 Biological and medical sciences Biomedical and Life Sciences Biomedicine Cadherins - metabolism Cancer Research Cancer therapies Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - etiology Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cyclooxygenase 2 Inhibitors - pharmacology Dehydrogenases Drug Resistance Epidemiology Epidermal growth factor Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - etiology Humans Hydroxyprostaglandin Dehydrogenases Medical prognosis Medical research Medical sciences Medicine Metastasis Molecular Diagnostics Molecular Medicine Neck Oncology Organic Anion Transporters - metabolism Pyrroles - pharmacology Smoking - adverse effects Squamous Cell Carcinoma of Head and Neck Sulfonamides - pharmacology Tobacco, tobacco smoking Toxicology Tumors Up-Regulation Vimentin - metabolism
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