A novel µ‐conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

BACKGROUND AND PURPOSE The µ‐conopeptide family is defined by its ability to block voltage‐gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ‐conopeptide (µ‐CnIIIC) on a range of preparations and...

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Veröffentlicht in:	British journal of pharmacology 2012-07, Vol.166 (5), p.1654-1668
Hauptverfasser:	Favreau, Philippe, Benoit, Evelyne, Hocking, Henry G, Carlier, Ludovic, D' hoedt, Dieter, Leipold, Enrico, Markgraf, René, Schlumberger, Sébastien, Córdova, Marco A, Gaertner, Hubert, Paolini‐Bertrand, Marianne, Hartley, Oliver, Tytgat, Jan, Heinemann, Stefan H, Bertrand, Daniel, Boelens, Rolf, Stöcklin, Reto, Molgó, Jordi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences cone snail venom Conotoxins - chemistry Conotoxins - pharmacology Conus Snail Esocidae Female HEK293 Cells Humans In Vitro Techniques Life Sciences Male Medical sciences Mice Molecular Sequence Data Muscle Contraction - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - physiology myorelaxant Neurons and Cognition nicotinic acetylcholine receptor Nicotinic Antagonists - chemistry Nicotinic Antagonists - pharmacology NMR structure Olfactory Nerve - drug effects Olfactory Nerve - physiology Oocytes Peptides - chemistry Peptides - pharmacology Pharmacology. Drug treatments Protein Conformation Receptors, Nicotinic - physiology Research Papers Sciatic Nerve - drug effects Sciatic Nerve - physiology Sodium Channel Blockers - chemistry Sodium Channel Blockers - pharmacology Sodium Channels - physiology twitch tension voltage‐gated sodium channel Xenopus laevis µ‐conotoxin
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