The effects of sorafenib on liver regeneration in a model of partial hepatectomy

Abstract Background Sorafenib is currently approved for advanced hepatocellular carcinoma (HCC) and is presently being studied as an adjuvant treatment for HCC following resection. The effects of sorafenib on liver regeneration have not been clearly defined. Our objective was to identify the effects...

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Veröffentlicht in:	The Journal of surgical research 2012-11, Vol.178 (1), p.242-247
Hauptverfasser:	Kurniali, Peter C., MD, O'Gara, Katie, Wang, Xiaofei, MD, Wang, Li Juan, MD, Somasundar, Ponnandai, MD, Falanga, Vincent, MD, Espat, N. Joseph, MD, Katz, Steven C., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzenesulfonates - pharmacology BrdU Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - surgery Cell Proliferation - drug effects Dose-Response Relationship, Drug Hepatectomy - methods Hepatocytes - drug effects Hepatocytes - physiology Ki67 Liver Cirrhosis - drug therapy Liver Cirrhosis - surgery Liver Neoplasms - drug therapy Liver Neoplasms - surgery Liver regeneration Liver Regeneration - drug effects Liver Regeneration - physiology Male Mice Mice, Inbred C57BL Models, Animal Niacinamide - analogs & derivatives Partial hepatectomy Phenylurea Compounds Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Sorafenib Surgery
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