R-subunit Isoform Specificity in Protein Kinase A: Distinct Features of Protein Interfaces in PKA Types I and II by Amide H/ 2H Exchange Mass Spectrometry

The two isoforms (RI and RII) of the regulatory (R) subunit of cAMP-dependent protein kinase or protein kinase A (PKA) are similar in sequence yet have different biochemical properties and physiological functions. To further understand the molecular basis for R-isoform-specificity, the interactions...

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Veröffentlicht in:	Journal of molecular biology 2007-11, Vol.374 (2), p.487-499
Hauptverfasser:	Anand, Ganesh S., Hotchko, Matthew, Brown, Simon H.J., Ten Eyck, Lynn F., Komives, Elizabeth A., Taylor, Susan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism amide H/ 2H exchange Amides - chemistry cAMP signaling Catalytic Domain Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - chemistry Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism Deuterium - chemistry Deuterium Exchange Measurement Holoenzymes - chemistry Holoenzymes - metabolism MALDI-TOF Mass Spectrometry Models, Molecular Peptide Fragments - chemistry Peptide Fragments - metabolism protein kinase A Protein Structure, Quaternary Protein Subunits - chemistry Protein Subunits - metabolism RIIβ isoform Surface Plasmon Resonance
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