Altered Balance of Proteolytic Isoforms of Pro–Brain-Derived Neurotrophic Factor in Autism

ABSTRACTDefects in synaptic development and plasticity may lead to autism. Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity. BDNF is synthesized as a precursor, pro-BDNF, which can be processed into either a truncated form or into mature BDNF....

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2012-04, Vol.71 (4), p.289-297
Hauptverfasser:	Garcia, Kristine L.P, Yu, Guanhua, Nicolini, Chiara, Michalski, Bernadeta, Garzon, Diego J, Chiu, Victor S, Tongiorgi, Enrico, Szatmari, Peter, Fahnestock, Margaret
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcoholism and acute alcohol poisoning Animal cognition Autism Autistic Disorder - diagnosis Autistic Disorder - genetics Autistic Disorder - metabolism Behavior Biological and medical sciences Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Child Child, Preschool Cognitive ability Female Humans Male Medical sciences Middle Aged Neurology Neuronal Plasticity - genetics Protein Isoforms - genetics Protein Isoforms - metabolism Protein Precursors - genetics Protein Precursors - metabolism Proteins Proteolysis RNA, Messenger - metabolism Schizophrenia Studies Synapses - genetics Toxicology Young Adult
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