Lysine Succinylation and Lysine Malonylation in Histones

Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified by MS/MS of synthetic...

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Veröffentlicht in:	Molecular & cellular proteomics 2012-05, Vol.11 (5), p.100-107
Hauptverfasser:	Xie, Zhongyu, Dai, Junbiao, Dai, Lunzhi, Tan, Minjia, Cheng, Zhongyi, Wu, Yeming, Boeke, Jef D., Zhao, Yingming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Cell Line Conserved Sequence DNA repair Drosophila Embryo fibroblasts Gene expression High-performance liquid chromatography Histones Histones - chemistry Histones - genetics Histones - metabolism Humans Lysine Lysine - metabolism Malonates - metabolism Metabolism Mice Molecular Sequence Data Mutagenesis Peptide Fragments - chemistry Phenotype Post-translation Protein Processing, Post-Translational Protein Structure, Tertiary proteomics Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Succinates - metabolism synthetic peptides Tandem Mass Spectrometry
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