Integrins as regulators of the mitotic machinery
Mitotic spindle bipolarity defines a unique division plane that promotes the successful transmission of genetic material during cytokinesis. The positioning and orientation of the spindle determines the symmetry of cell division and the relative location of daughter cells, which regulate cell fate d...
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| Veröffentlicht in: | Current opinion in cell biology 2008-10, Vol.20 (5), p.576-582 |
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| container_title | Current opinion in cell biology |
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| creator | LaFlamme, Susan E Nieves, Bethsaida Colello, Diane Reverte, Carlos G |
| description | Mitotic spindle bipolarity defines a unique division plane that promotes the successful transmission of genetic material during cytokinesis. The positioning and orientation of the spindle determines the symmetry of cell division and the relative location of daughter cells, which regulate cell fate decisions that contribute to embryonic development and tissue differentiation. Recent studies have identified integrins as regulators of spindle positioning and orientation, as well as spindle bipolarity and cytokinesis. This review summarizes and discusses the current effort focused on understanding how integrins regulate these mitotic events. |
| doi_str_mv | 10.1016/j.ceb.2008.06.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0955-0674 |
| ispartof | Current opinion in cell biology, 2008-10, Vol.20 (5), p.576-582 |
| issn | 0955-0674 1879-0410 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Humans Integrins - metabolism Internal Medicine Microtubules - metabolism Mitosis - physiology Signal Transduction - physiology Spindle Apparatus - chemistry Spindle Apparatus - metabolism |
| title | Integrins as regulators of the mitotic machinery |
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