Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers

Poly(ADP-ribose) (pADPr) is a large, structurally complex polymer of repeating ADP-ribose units. It is biosynthesized from NAD+ by poly(ADP-ribose) polymerases (PARPs) and degraded to ADP-ribose by poly(ADP-ribose) glycohydrolase. pADPr is involved in many cellular processes and exerts biological fu...

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Veröffentlicht in:	Analytical biochemistry 2012-09, Vol.428 (2), p.126-136
Hauptverfasser:	Tan, Edwin S., Krukenberg, Kristin A., Mitchison, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP ADP-ribose ADPr Animals anion exchange chromatography binding proteins Biocatalysis Biochemistry - methods Biopolymers - biosynthesis Biopolymers - chemistry Calibration Cattle Chemical Fractionation Chromatography, High Pressure Liquid Glycoside Hydrolases - chemistry Glycoside Hydrolases - isolation & purification Glycoside Hydrolases - metabolism Humans NAD pADPr PAR PARG PARP Poly Adenosine Diphosphate Ribose - biosynthesis Poly Adenosine Diphosphate Ribose - chemistry Poly(ADP-ribose) Poly(ADP-ribose) glycohydrolase Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - chemistry Poly(ADP-ribose) Polymerases - metabolism Polymer Polymerization polymers Protein Structure, Tertiary purification methods structure-activity relationships Tankyrases - chemistry Tankyrases - isolation & purification Tankyrases - metabolism
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