A systematic comparison of quantitative high-resolution DNA methylation analysis and methylation-specific PCR

Assessment of DNA methylation has become a critical factor for the identification, development and application of methylation based biomarkers. Here we describe a systematic comparison of a quantitative high-resolution mass spectrometry-based approach (MassARRAY), pyrosequencing and the broadly used...

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Veröffentlicht in:	Epigenetics 2012-07, Vol.7 (7), p.772-780
Hauptverfasser:	Claus, Rainer, Wilop, Stefan, Hielscher, Thomas, Sonnet, Miriam, Dahl, Edgar, Galm, Oliver, Jost, Edgar, Plass, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics 5-Methylcytosine - analysis Aged Aged, 80 and over AML Binding Biology biomarker Bioscience Calcium Cancer Cell Cycle DNA Methylation Female High-Throughput Nucleotide Sequencing Humans ID4 Inhibitor of Differentiation Proteins - genetics Landes Leukemia, Myeloid, Acute - genetics Male Mass Spectrometry MassARRAY Middle Aged MSP Organogenesis Polymerase Chain Reaction - methods Proteins pyrosequencing quantitative DNA methylation analysis Research Paper Sensitivity and Specificity Sequence Analysis, DNA - methods SFRP Young Adult
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