Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation

Key points • We show that parenchymal arterioles of less than 30 μm in diameter can be successfully cannulated and perfused in cortical and hypothalamic brain slices. • Increased flow/pressure induced parenchymal arteriolar constriction. • Alternatively to video microscopy, diameter measurements...

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Veröffentlicht in:	The Journal of physiology 2012-04, Vol.590 (7), p.1757-1770
Hauptverfasser:	Kim, Ki Jung, Filosa, Jessica A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arterioles Arterioles - physiology Blood Pressure Brain slice preparation Cannulation Cerebral Cortex - blood supply Cerebral Cortex - physiology Cortex Fluorescence Fluorescence recovery after photobleaching Glutamic acid receptors (metabotropic) Hemodynamics Hypothalamus Hypothalamus - blood supply Hypothalamus - physiology Male Microcirculation Microscopy Neurosceince: Neurobiology of Disease Perfusion pH effects Potassium Pressure Rats Rats, Wistar Regional Blood Flow Supraoptic nucleus Vasoconstriction Vasodilation
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