Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development

Mutations in the human Shwachman-Bodian-Diamond syndrome (SBDS) gene cause defective ribosome assembly and are associated with exocrine pancreatic insufficiency, chronic neutropenia and skeletal defects. However, the mechanism underlying these phenotypes remains unclear. Here we show that knockdown...

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Veröffentlicht in:	Development (Cambridge) 2012-09, Vol.139 (17), p.3232-3241
Hauptverfasser:	Provost, Elayne, Wehner, Karen A, Zhong, Xiangang, Ashar, Foram, Nguyen, Elizabeth, Green, Rachel, Parsons, Michael J, Leach, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcian Blue Animals Anthraquinones Bone Marrow Diseases - genetics Danio rerio Disease Models, Animal Exocrine Pancreatic Insufficiency - genetics Fluorescent Antibody Technique Gene Expression Profiling Gene Knockdown Techniques In Situ Hybridization Lipomatosis - genetics Nuclear Proteins - deficiency Nuclear Proteins - genetics Oligonucleotide Array Sequence Analysis Pancreas - embryology Pancreas - metabolism Ribosomal Proteins - deficiency Ribosomal Proteins - genetics Ribosomes - genetics Ribosomes - metabolism Shwachman-Diamond Syndrome Tumor Suppressor Protein p53 - metabolism Zebrafish Zebrafish Proteins - deficiency Zebrafish Proteins - genetics
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