Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment

DNA methylation has been implicated as an epigenetic component of mechanisms that stabilize cell-fate decisions. Here, we have characterized the methylomes of human female hematopoietic stem/progenitor cells (HSPCs) and mature cells from the myeloid and lymphoid lineages. Hypomethylated regions (HMR...

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Veröffentlicht in:	Molecular cell 2011-10, Vol.44 (1), p.17-28
Hauptverfasser:	Hodges, Emily, Molaro, Antoine, Dos Santos, Camila O., Thekkat, Pramod, Song, Qiang, Uren, Philip J., Park, Jin, Butler, Jason, Rafii, Shahin, McCombie, W. Richard, Smith, Andrew D., Hannon, Gregory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults Binding Sites Cell Differentiation Cell Lineage cells Comparative Genomic Hybridization data collection DNA Methylation Epigenesis, Genetic epigenetics Female females Gene Expression Regulation genes Genome, Human Hematopoietic Stem Cells - cytology Hematopoietic System Humans methylation Models, Biological Promoter Regions, Genetic stem cells
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