Correlation of selenium and zinc levels to antiretroviral treatment outcomes in Thai HIV-infected children without severe HIV symptoms

Background/Objectives: Deficiencies in antioxidants contribute to immune dysregulation and viral replication. To evaluate the correlation of selenium (Se) and zinc (Zn) levels on the treatment outcomes in HIV-infected children. Subjects/Methods: HIV-infected Thai children 1–12 years old, CD4 15–24%,...

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Veröffentlicht in:	European journal of clinical nutrition 2012-08, Vol.66 (8), p.900-905
Hauptverfasser:	Bunupuradah, T, Ubolyam, S, Hansudewechakul, R, Kosalaraksa, P, Ngampiyaskul, C, Kanjanavanit, S, Wongsawat, J, Luesomboon, W, Pinyakorn, S, Kerr, S, Ananworanich, J, Chomtho, S, van der Lugt, J, Luplertlop, N, Ruxrungtham, K, Puthanakit, T
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/1702 692/699/255/1901 692/700/459/1994 692/700/478 Absorption Anti-HIV Agents - therapeutic use Antioxidants Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - methods Antiviral agents Atomic absorption spectroscopy Biological and medical sciences C-reactive protein C-Reactive Protein - metabolism Care and treatment CD4 antigen CD4 Lymphocyte Count Child Child, Preschool Children Children & youth Clinical Nutrition Clinical outcomes Correlation Demographic aspects Epidemiology Feeding. Feeding behavior Female Ferritin Fundamental and applied biological sciences. Psychology Health aspects HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - epidemiology HIV patients HIV-1 - drug effects Human immunodeficiency virus Human viral diseases Humans Infectious diseases Internal Medicine Linear Models Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Micronutrients - blood Multivariate analysis original-article Physiological aspects Public Health Ribonucleic acid RNA RNA, Viral - isolation & purification Selenium Selenium - blood Spectral analysis Spectrometry Thailand - epidemiology Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Zinc Zinc - blood Zinc in the body
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Beschreibung
Zusammenfassung:	Background/Objectives: Deficiencies in antioxidants contribute to immune dysregulation and viral replication. To evaluate the correlation of selenium (Se) and zinc (Zn) levels on the treatment outcomes in HIV-infected children. Subjects/Methods: HIV-infected Thai children 1–12 years old, CD4 15–24%, without severe HIV symptoms were included. Se and Zn levels were measured by graphite furnace atomic absorption spectrometry at baseline and 48 weeks. Deficiency cutoffs were Se
ISSN:	0954-3007 1476-5640
DOI:	10.1038/ejcn.2012.57