Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells

We have previously demonstrated that hypoxia stimulates adipose-derived stem cells (ASCs) through the generation of reactive oxygen species (ROS). However, the precise mechanism involved in the ROS generation by ASCs is not well understood. We sought to investigate in this work: (1) which subtype of...

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Veröffentlicht in:	Stem cells and development 2012-08, Vol.21 (12), p.2212-2221
Hauptverfasser:	Kim, Ji Hye, Song, Seung-Yong, Park, Sang Gyu, Song, Sun U., Xia, Ying, Sung, Jong-Hyuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - enzymology Adult Stem Cells - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Hypoxia Cell Movement Cell Nucleus - enzymology Cell Proliferation Cells, Cultured Gene Expression Gene Knockdown Techniques Humans Mitochondria - enzymology NADPH Oxidase 4 NADPH Oxidases - genetics NADPH Oxidases - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Original Research Reports Reactive Oxygen Species - metabolism RNA Interference Signal Transduction Subcutaneous Fat - cytology
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