Synthesis of CJ-15,208, a novel κ-opioid receptor antagonist

A strategy to select linear precursor peptides favoring cyclization was developed and cyclization conditions were optimized. The tryptophan isomers of the cyclic tetrapeptide CJ-15,208, reported to be a kappa opioid receptor (KOR) antagonist [Saito, T.; Hirai, H.; Kim, Y. J.; Kojima, Y.; Matsunaga,...

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Veröffentlicht in:	Tetrahedron letters 2010-09, Vol.51 (38), p.5020-5023
Hauptverfasser:	Ross, Nicolette C., Kulkarni, Santosh S., McLaughlin, Jay P., Aldrich, Jane V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclic tetrapeptide Cyclization Molecular modeling
Online-Zugang:	Volltext
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