Biocompatibility and biofilm inhibition of N , N -hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials

Abstract The biocompatibility and antibacterial properties of N , N -hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibi...

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Veröffentlicht in:	Biomaterials 2011-12, Vol.32 (34), p.8783-8796
Hauptverfasser:	Behlau, Irmgard, Mukherjee, Koushik, Todani, Amit, Tisdale, Ann S, Cade, Fabiano, Wang, Liqiang, Leonard, Elizabeth M, Zakka, Fouad R, Gilmore, Michael S, Jakobiec, Frederick A, Dohlman, Claes H, Klibanov, Alexander M
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial antibacterial properties biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology biofilm Biofilms - drug effects cornea Cornea - cytology Cornea - drug effects Corneal cytotoxicity cytotoxicity Dentistry electron microscopy epithelial cells Keratoprosthesis PMMA Polyethyleneimine - chemistry Polyethyleneimine - pharmacology Polyethylenimine (PEI) Polymethyl Methacrylate - chemistry Polymethyl Methacrylate - pharmacology Prostheses and Implants Rabbits Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Titanium Titanium - chemistry Titanium - pharmacology
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