Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3

Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting myofibroblasts resulting in lung scaring. The prognosis is poor and there are no effective therapies or reliable biomark...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2012-03, Vol.185 (5), p.537-546
Hauptverfasser:	MACKINNON, Alison C, GIBBONS, Michael A, SETHI, Tariq, FARNWORTH, Sarah L, LEFFLER, Hakon, NILSSON, Uif J, DELAINE, Tamara, JOHN SIMPSON, A, FORBES, Stuart J, HIRANI, Nik, GAULDIE, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bleomycin - toxicity Blood and lymphatic vessels Cardiology. Vascular system Collagen - biosynthesis Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fibroblasts - metabolism Fibroblasts - physiology Fluorescent Antibody Technique Galectin 3 - antagonists & inhibitors Galectin 3 - physiology Gene Knockout Techniques Humans Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - physiopathology Intensive care medicine Lung - pathology Medical sciences Mice Mice, Inbred C57BL Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Pulmonary Fibrosis - physiopathology Signal Transduction - physiology Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - physiology
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