Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3
Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form a multinucleated myotube with nuclei positioned in the centre of the syncytium by an unknown mechanism. Here, we describe that the nucleus of...
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| Veröffentlicht in: | EMBO reports 2012-08, Vol.13 (8), p.741-749 |
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| creator | Cadot, Bruno Gache, Vincent Vasyutina, Elena Falcone, Sestina Birchmeier, Carmen Gomes, Edgar R |
| description | Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form a multinucleated myotube with nuclei positioned in the centre of the syncytium by an unknown mechanism. Here, we describe that the nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei. This movement is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. We found that Par6β and dynactin accumulate at the nuclear envelope of differentiated myoblasts and myotubes, and this accumulation is dependent on Par6 and Par3 proteins but not on microtubules. These results suggest a mechanism where nuclear movement after fusion is driven by microtubules that emanate from one nucleus that are pulled by dynein/dynactin complex anchored to the nuclear envelope of another nucleus.
Mono‐nucleated myoblasts fuse to form multi‐nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3. |
| doi_str_mv | 10.1038/embor.2012.89 |
| format | Article |
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Mono‐nucleated myoblasts fuse to form multi‐nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3.</description><identifier>ISSN: 1469-221X</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.1038/embor.2012.89</identifier><identifier>PMID: 22732842</identifier><identifier>CODEN: ERMEAX</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - metabolism ; Animals ; cdc42 GTP-Binding Protein - metabolism ; Cell adhesion & migration ; Cell Adhesion Molecules - metabolism ; Cell Fusion ; Cell Line ; Cell Nucleus - metabolism ; Cellular Biology ; Dynactin Complex ; dynein ; Dyneins - metabolism ; EMBO05 ; Life Sciences ; Mice ; Microtubule-Associated Proteins - metabolism ; microtubules ; Microtubules - metabolism ; Models, Biological ; Muscle Fibers, Skeletal - cytology ; Muscle Fibers, Skeletal - metabolism ; Myoblasts - cytology ; Myoblasts - metabolism ; Nuclear Envelope - metabolism ; nuclear movement ; Par6 ; Protein Transport ; Proteins ; Scientific Report ; Scientific Reports ; skeletal muscle</subject><ispartof>EMBO reports, 2012-08, Vol.13 (8), p.741-749</ispartof><rights>European Molecular Biology Organization 2012</rights><rights>Copyright © 2012 European Molecular Biology Organization</rights><rights>Copyright Nature Publishing Group Aug 2012</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2012, European Molecular Biology Organization 2012 European Molecular Biology Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6389-fdc94777694cbbd04caeba48280c38e52d13aa377c450d73e493910a635e2ec13</citedby><cites>FETCH-LOGICAL-c6389-fdc94777694cbbd04caeba48280c38e52d13aa377c450d73e493910a635e2ec13</cites><orcidid>0000-0002-2041-8872 ; 0000-0002-1888-3898 ; 0000-0002-2928-791X ; 0000-0002-3574-0602 ; 0000-0002-6941-4872</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410389/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410389/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22732842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03687577$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cadot, Bruno</creatorcontrib><creatorcontrib>Gache, Vincent</creatorcontrib><creatorcontrib>Vasyutina, Elena</creatorcontrib><creatorcontrib>Falcone, Sestina</creatorcontrib><creatorcontrib>Birchmeier, Carmen</creatorcontrib><creatorcontrib>Gomes, Edgar R</creatorcontrib><title>Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form a multinucleated myotube with nuclei positioned in the centre of the syncytium by an unknown mechanism. Here, we describe that the nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei. This movement is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. We found that Par6β and dynactin accumulate at the nuclear envelope of differentiated myoblasts and myotubes, and this accumulation is dependent on Par6 and Par3 proteins but not on microtubules. These results suggest a mechanism where nuclear movement after fusion is driven by microtubules that emanate from one nucleus that are pulled by dynein/dynactin complex anchored to the nuclear envelope of another nucleus.
Mono‐nucleated myoblasts fuse to form multi‐nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3.</description><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>cdc42 GTP-Binding Protein - metabolism</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Fusion</subject><subject>Cell Line</subject><subject>Cell Nucleus - metabolism</subject><subject>Cellular Biology</subject><subject>Dynactin Complex</subject><subject>dynein</subject><subject>Dyneins - metabolism</subject><subject>EMBO05</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>microtubules</subject><subject>Microtubules - metabolism</subject><subject>Models, Biological</subject><subject>Muscle Fibers, Skeletal - cytology</subject><subject>Muscle Fibers, Skeletal - metabolism</subject><subject>Myoblasts - cytology</subject><subject>Myoblasts - 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One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form a multinucleated myotube with nuclei positioned in the centre of the syncytium by an unknown mechanism. Here, we describe that the nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei. This movement is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. We found that Par6β and dynactin accumulate at the nuclear envelope of differentiated myoblasts and myotubes, and this accumulation is dependent on Par6 and Par3 proteins but not on microtubules. These results suggest a mechanism where nuclear movement after fusion is driven by microtubules that emanate from one nucleus that are pulled by dynein/dynactin complex anchored to the nuclear envelope of another nucleus.
Mono‐nucleated myoblasts fuse to form multi‐nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>22732842</pmid><doi>10.1038/embor.2012.89</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2041-8872</orcidid><orcidid>https://orcid.org/0000-0002-1888-3898</orcidid><orcidid>https://orcid.org/0000-0002-2928-791X</orcidid><orcidid>https://orcid.org/0000-0002-3574-0602</orcidid><orcidid>https://orcid.org/0000-0002-6941-4872</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - metabolism Animals cdc42 GTP-Binding Protein - metabolism Cell adhesion & migration Cell Adhesion Molecules - metabolism Cell Fusion Cell Line Cell Nucleus - metabolism Cellular Biology Dynactin Complex dynein Dyneins - metabolism EMBO05 Life Sciences Mice Microtubule-Associated Proteins - metabolism microtubules Microtubules - metabolism Models, Biological Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Myoblasts - cytology Myoblasts - metabolism Nuclear Envelope - metabolism nuclear movement Par6 Protein Transport Proteins Scientific Report Scientific Reports skeletal muscle |
| title | Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3 |
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