Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats
Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. Af...
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| description | Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes. The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally). In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism. Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes. BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg. These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages. |
| doi_str_mv | 10.1155/2012/578497 |
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The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes. The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally). In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism. Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes. BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg. These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2012/578497</identifier><identifier>PMID: 22888365</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alanine ; Alanine transaminase ; Antioxidants ; Biochemistry ; Bupleurum ; Catalase ; Endocrinology ; Enzymes ; Free radicals ; Glutathione ; Hormones ; Hyperthyroidism ; Laboratory animals ; Lipid peroxidation ; Lipids ; Liver ; Metabolism ; Oral administration ; Oxidative stress ; Peroxidation ; Physiology ; Propylthiouracil ; Rodentia ; Rodents ; Superoxide dismutase ; Thyroid gland ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroxine ; Triiodothyronine</subject><ispartof>Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-12</ispartof><rights>Copyright © 2012 Seong-Mo Kim et al.</rights><rights>Copyright © 2012 Seong-Mo Kim et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2012 Seong-Mo Kim et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-61f81a5e62890f2dbbfaf6aa8d646a81b1e0d6da379e013b2246e79ebcc469413</citedby><cites>FETCH-LOGICAL-c430t-61f81a5e62890f2dbbfaf6aa8d646a81b1e0d6da379e013b2246e79ebcc469413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410357/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410357/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22888365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chang, Il-Moo</contributor><contributor>Il-Moo Chang</contributor><creatorcontrib>Cheon, Woo-Hyun</creatorcontrib><creatorcontrib>Chung, In-Kwon</creatorcontrib><creatorcontrib>Kim, Sang Chan</creatorcontrib><creatorcontrib>Kim, Seong-Mo</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><title>Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes. The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally). In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism. Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes. BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg. These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Bupleurum</subject><subject>Catalase</subject><subject>Endocrinology</subject><subject>Enzymes</subject><subject>Free radicals</subject><subject>Glutathione</subject><subject>Hormones</subject><subject>Hyperthyroidism</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Oral administration</subject><subject>Oxidative stress</subject><subject>Peroxidation</subject><subject>Physiology</subject><subject>Propylthiouracil</subject><subject>Rodentia</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Triiodothyronine</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc9rFDEYhgdRbK2evEvAiyhj82uSzEWopdpCQZEK3kJm8sVNnUm2Saa6_71Zti7Vk6e85Hvy8IW3aZ4T_JaQrjummNDjTireywfNIZGctJwq9XCf5beD5knO1xjTXkr5uDmgda6Y6A6bHyeh-PjLWxMKMsGizykWGIu_BXTmXE0ZRYfeL-sJlrTMyJlpNKWGGFBZAZraq9UmVUOA9iLYZQSLzjdrSGV77a3PM_IBfTElP20e1dcZnt2dR83XD2dXp-ft5aePF6cnl-3IGS6tIE4R04GgqseO2mFwxgljlBVcGEUGAtgKa5jsARM2UMoF1DyMIxc9J-yoebfzrpdhBjtCKMlMep38bNJGR-P135PgV_p7vNWME8w6WQWv7gQp3iyQi559HmGaTIC4ZF0pLvuOMFrRl_-g13FJoX5PUyywwpLRrfDNjhpTzDmB2y9DsN6WqLcl6l2JlX5xf_89-6e1CrzeASsfrPnp_88GFQFn7sFUcUzZbxPnr8s</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Cheon, Woo-Hyun</creator><creator>Chung, In-Kwon</creator><creator>Kim, Sang Chan</creator><creator>Kim, Seong-Mo</creator><creator>Ku, Sae-Kwang</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats</title><author>Cheon, Woo-Hyun ; Chung, In-Kwon ; Kim, Sang Chan ; Kim, Seong-Mo ; Ku, Sae-Kwang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-61f81a5e62890f2dbbfaf6aa8d646a81b1e0d6da379e013b2246e79ebcc469413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Bupleurum</topic><topic>Catalase</topic><topic>Endocrinology</topic><topic>Enzymes</topic><topic>Free radicals</topic><topic>Glutathione</topic><topic>Hormones</topic><topic>Hyperthyroidism</topic><topic>Laboratory animals</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Oral administration</topic><topic>Oxidative stress</topic><topic>Peroxidation</topic><topic>Physiology</topic><topic>Propylthiouracil</topic><topic>Rodentia</topic><topic>Rodents</topic><topic>Superoxide dismutase</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>Triiodothyronine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheon, Woo-Hyun</creatorcontrib><creatorcontrib>Chung, In-Kwon</creatorcontrib><creatorcontrib>Kim, Sang Chan</creatorcontrib><creatorcontrib>Kim, Seong-Mo</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheon, Woo-Hyun</au><au>Chung, In-Kwon</au><au>Kim, Sang Chan</au><au>Kim, Seong-Mo</au><au>Ku, Sae-Kwang</au><au>Chang, Il-Moo</au><au>Il-Moo Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes. The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally). In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism. Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes. BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg. These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>22888365</pmid><doi>10.1155/2012/578497</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alanine Alanine transaminase Antioxidants Biochemistry Bupleurum Catalase Endocrinology Enzymes Free radicals Glutathione Hormones Hyperthyroidism Laboratory animals Lipid peroxidation Lipids Liver Metabolism Oral administration Oxidative stress Peroxidation Physiology Propylthiouracil Rodentia Rodents Superoxide dismutase Thyroid gland Thyroid hormones Thyroid-stimulating hormone Thyroxine Triiodothyronine |
| title | Antioxidant and Protective Effects of Bupleurum falcatum on the l-Thyroxine-Induced Hyperthyroidism in Rats |
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