Hyperandrogenism Sensitizes Leukocytes to Hyperglycemia to Promote Oxidative Stress in Lean Reproductive-Age Women

Context: Hyperandrogenism and oxidative stress are related in polycystic ovary syndrome (PCOS), but it is unknown whether hyperandrogenemia can activate oxidative stress. Objective: The purpose of this study was to determine the effect of oral androgen administration on fasting and glucose-stimulate...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2012-08, Vol.97 (8), p.2836-2843
Hauptverfasser:	González, Frank, Nair, K. Sreekumaran, Daniels, Janice K, Basal, Eati, Schimke, Jill M, Blair, Hilary E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Glucose - analysis Body Composition Dehydroepiandrosterone - pharmacology Dehydroepiandrosterone Sulfate - blood Double-Blind Method Endocrine Research Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Hyperandrogenism - metabolism Hyperglycemia - metabolism Leukocytes - metabolism Medical sciences NADPH Oxidases - genetics Oxidative Stress Polycystic Ovary Syndrome - metabolism Reactive Oxygen Species - metabolism Testosterone - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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