A specific role for TLR1 in protective TH17 immunity during mucosal infection

The balance between regulatory and inflammatory immune responses is critical to maintain intestinal homeostasis. Furthermore, the nature of the inflammatory response needs to be tailored to the tissue to provide proper protective immunity while preserving host integrity. TLR2 (Toll-like receptor 2)...

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Veröffentlicht in:The Journal of experimental medicine 2012-07, Vol.209 (8), p.1437-1444
Hauptverfasser: DePaolo, R. William, Kamdar, Karishma, Khakpour, Samira, Sugiura, Yui, Wang, Wenxia, Jabri, Bana
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container_issue 8
container_start_page 1437
container_title The Journal of experimental medicine
container_volume 209
creator DePaolo, R. William
Kamdar, Karishma
Khakpour, Samira
Sugiura, Yui
Wang, Wenxia
Jabri, Bana
description The balance between regulatory and inflammatory immune responses is critical to maintain intestinal homeostasis. Furthermore, the nature of the inflammatory response needs to be tailored to the tissue to provide proper protective immunity while preserving host integrity. TLR2 (Toll-like receptor 2) is a unique TLR in that it has been shown to promote regulatory and inflammatory T cell responses. Using Yersinia enterocolitica, we show that oral infection promotes TH17 immunity, whereas systemic infection promotes TH1 immunity. Furthermore, induction of TH17 immunity during oral infection is dependent on TLR1 and results from the combinatorial effect of TLR2/TLR1-induced IL-6 and IL-23 and the presence of TGF-β in the intestinal environment. Interestingly, TLR2/TLR1 was not involved in TH1 immune responses during systemic infection, whereas the TLR2/TLR6 receptor complex induced IL-10+ regulatory T cell responses during both systemic and oral infections. Our results reveal that the route of infection is central in determining which pathways provide protective immunity. Furthermore, they also demonstrate that TLR2 has dual immune functions in the gut and identify TLR1 as a critical innate receptor for protective intestinal TH17 immunity.
doi_str_mv 10.1084/jem.20112339
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Yersinia enterocolitica
title A specific role for TLR1 in protective TH17 immunity during mucosal infection
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