NK Cells Modulate the Inflammatory Response to Corneal Epithelial Abrasion and Thereby Support Wound Healing

Natural killer (NK) cells are lymphocytes of the innate immune system that have crucial cytotoxic and regulatory roles in adaptive immunity and inflammation. Herein, we consider a role for these cells in corneal wound healing. After a 2-mm central epithelial abrasion of the mouse cornea, a subset of...

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Veröffentlicht in:	The American journal of pathology 2012-08, Vol.181 (2), p.452-462
Hauptverfasser:	Liu, Qiong, Smith, C. Wayne, Zhang, Wanyu, Burns, Alan R, Li, Zhijie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Biological and medical sciences Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - metabolism Cell Movement - immunology Epithelium, Corneal - immunology Epithelium, Corneal - pathology Female Inflammation - immunology Inflammation - pathology Investigative techniques, diagnostic techniques (general aspects) Killer Cells, Natural - immunology Lymphocyte Depletion Medical sciences Mice Mice, Inbred C57BL NK Cell Lectin-Like Receptor Subfamily K - antagonists & inhibitors NK Cell Lectin-Like Receptor Subfamily K - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, CCR2 - metabolism Receptors, CXCR3 - metabolism Regular Spleen - immunology Wound Healing - immunology
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