Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites

DNA methylation is an essential epigenetic mark that is required for normal development. Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment reveals that methylation is critical for hematopoietic differentiation. To better understand the role of DNA methylation in he...

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Veröffentlicht in:	Genome research 2012-08, Vol.22 (8), p.1407-1418
Hauptverfasser:	Hogart, Amber, Lichtenberg, Jens, Ajay, Subramanian S, Anderson, Stacie, Margulies, Elliott H, Bodine, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Differentiation Chromatin Immunoprecipitation Chromosome Mapping - methods CpG Islands DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Erythroblasts - cytology Erythroblasts - metabolism GA-Binding Protein Transcription Factor - genetics GA-Binding Protein Transcription Factor - metabolism Gene Expression Regulation, Developmental Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Myeloid Cells - cytology Myeloid Cells - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleotide Motifs Promoter Regions, Genetic Protein Binding Transcription Factors - genetics Transcription Factors - metabolism Transcriptome
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