Structure−Activity Relationship of Uridine 5‘-Diphosphoglucose Analogues as Agonists of the Human P2Y14 Receptor

UDP-glucose (UDPG) and derivatives are naturally occurring agonists of the Gi protein-coupled P2Y14 receptor, which occurs in the immune system. We synthesized and characterized pharmacologically novel analogues of UDPG modified on the nucleobase, ribose, and glucose moieties, as the basis for desig...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-05, Vol.50 (9), p.2030-2039
Hauptverfasser:	Ko, Hyojin, Fricks, Ingrid, Ivanov, Andrei A, Harden, T. Kendall, Jacobson, Kenneth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Chlorocebus aethiops COS Cells Humans Medical sciences Models, Molecular Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Purinergic P2 Receptor Agonists Receptors, Purinergic P2 Recombinant Proteins - agonists Stereoisomerism Structure-Activity Relationship Uridine Diphosphate Glucose - analogs & derivatives Uridine Diphosphate Glucose - chemical synthesis Uridine Diphosphate Glucose - pharmacology
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