Molecular Characteristics of Clostridium perfringens TpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living Cells

Background: TpeL is a member of the family of clostridial glucosylating toxins, produced by Clostridium perfringens. Results: TpeL enters target cells by self-mediated entry and mono-glycosylates Ras proteins at Thr-35. Conclusion: TpeL inhibits Ras signaling and induces apoptosis in target cells. S...

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Veröffentlicht in:	The Journal of biological chemistry 2012-07, Vol.287 (30), p.24929-24940
Hauptverfasser:	Guttenberg, Gregor, Hornei, Sven, Jank, Thomas, Schwan, Carsten, Lü, Wei, Einsle, Oliver, Papatheodorou, Panagiotis, Aktories, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - genetics Acetylglucosamine - metabolism Animals Apoptosis Apoptosis - genetics Bacterial Glucosyltransferases Bacterial Pathogenesis Bacterial Toxins Bacterial Toxins - genetics Bacterial Toxins - metabolism Clostridial Glucosylating Toxins Clostridium perfringens Clostridium perfringens - enzymology Clostridium perfringens - genetics Enzyme Activation - genetics Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Glycosylation Glycosyltransferases Glycosyltransferases - genetics Glycosyltransferases - metabolism HeLa Cells Humans Microbiology Oncogene Protein p21(ras) - genetics Oncogene Protein p21(ras) - metabolism PC12 Cells Proteolysis raf Kinases - genetics raf Kinases - metabolism Ras Ras Signaling Rats Uridine Diphosphate Sugars - genetics Uridine Diphosphate Sugars - metabolism
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