Bone Marrow Mesenchymal Stem Cells Stimulate Cardiac Stem Cell Proliferation and Differentiation

RATIONALE:The regenerative potential of the heart is insufficient to fully restore functioning myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone marrow–derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capa...

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Veröffentlicht in:	Circulation research 2010-10, Vol.107 (7), p.913-922
Hauptverfasser:	Hatzistergos, Konstantinos E, Quevedo, Henry, Oskouei, Behzad N, Hu, Qinghua, Feigenbaum, Gary S, Margitich, Irene S, Mazhari, Ramesh, Boyle, Andrew J, Zambrano, Juan P, Rodriguez, Jose E, Dulce, Raul, Pattany, Pradip M, Valdes, David, Revilla, Concepcion, Heldman, Alan W, McNiece, Ian, Hare, Joshua M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biopsy Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cardiology. Vascular system Cell Communication - physiology Cell Differentiation - physiology Cell Division - physiology Cells, Cultured Coculture Techniques Coronary heart disease Coronary Vessels - cytology Coronary Vessels - physiology Culture Media, Conditioned - pharmacology Female Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - genetics Heart Medical sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Myocardial Infarction - pathology Myocardial Infarction - therapy Myocarditis. Cardiomyopathies Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Proto-Oncogene Proteins c-kit - metabolism Regeneration - physiology Sus scrofa Vertebrates: cardiovascular system
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