Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections

The mechanisms underlying the modulation of both the malaria-specific immune response and the course of clinical malaria in the context of concomitant helminth infection are poorly understood. We used multiparameter flow cytometry to characterize the quality and the magnitude of malaria-specific T c...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-04, Vol.186 (8), p.4725-4733
Hauptverfasser:	Metenou, Simon, Dembele, Benoit, Konate, Siaka, Dolo, Housseini, Coulibaly, Yaya I, Diallo, Abdallah A, Soumaoro, Lamine, Coulibaly, Michel E, Coulibaly, Siaka Y, Sanogo, Dramane, Doumbia, Salif S, Traoré, Sekou F, Mahanty, Siddhartha, Klion, Amy, Nutman, Thomas B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Child Comorbidity Female Filariasis - epidemiology Filariasis - immunology Filariasis - parasitology Filarioidea - immunology Flow Cytometry Humans Interleukin-10 - immunology Interleukin-10 - metabolism Interleukin-17 - immunology Interleukin-17 - metabolism Interleukin-4 - immunology Interleukin-4 - metabolism Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Mali - epidemiology Plasmodium falciparum T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th1 Cells - immunology Th1 Cells - metabolism Th17 Cells - immunology Th17 Cells - metabolism Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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