MEK/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells

► In this study, we examined the mechanism of insulin promoted MKP-3 protein degradation in cultured liver cells. ► We demonstrated that the MEK/ERK pathway mediates the effect of insulin on degrading MKP-3 protein. ► We further confirmed that ERK phosphorylation deficient MKP-3 mutant is resistant...

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Veröffentlicht in:	Molecular and cellular endocrinology 2012-09, Vol.361 (1-2), p.116-123
Hauptverfasser:	Feng, Bin, Jiao, Ping, Yang, Zaiqing, Xu, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals cycloheximide Degradation Dual Specificity Phosphatase 6 - metabolism Enzyme Activation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects genes Gluconeogenesis - drug effects Gluconeogenesis - genetics Glucose Glucose - metabolism Glucose output Glucose-6-Phosphatase - genetics Glucose-6-Phosphatase - metabolism hepatocytes Hepatocytes - drug effects Hepatocytes - enzymology homeostasis Humans Inhibitors Insulin Insulin - pharmacology insulin resistance Liver liver protein MAP kinase phosphatase MAP Kinase Signaling System - drug effects Mice Mice, Inbred C57BL mitogen-activated protein kinase Mutant Proteins - metabolism mutation Pathways phosphorylation Phosphorylation - drug effects Protein degradation protein synthesis Proteins Proteolysis - drug effects quantitative polymerase chain reaction Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism transcription (genetics)
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