Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14 Gene) Causes Severe Perturbations in Vitamin E Metabolism

Background: Human CYP4F2 metabolizes vitamin E, but its role in vivo is unknown. Results: Disruption of Cyp4f14, a murine ortholog of CYP4F2, severely alters vitamin E metabolism and status. Conclusion: CYP4F14 is an important regulator of vitamin E status, and its absence reveals counterbalancing m...

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Veröffentlicht in:	The Journal of biological chemistry 2012-07, Vol.287 (31), p.26077-26086
Hauptverfasser:	Bardowell, Sabrina A., Duan, Faping, Manor, Danny, Swanson, Joy E., Parker, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochrome P450 Family 4 Feces - chemistry Female Gene Expression Gene Knockout Techniques Homologous Recombination Hydroxylation Liver - enzymology Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Microsomes, Liver - enzymology Mixed Function Oxygenases - genetics Tocopherol Tocopherols - chemistry Tocopherols - metabolism Tocopherols - urine Vitamin E
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