Absence of a Human DnaJ Protein hTid-1S Correlates with Aberrant Actin Cytoskeleton Organization in Lesional Psoriatic Skin

Background: HSP27 phosphorylation plays pivotal roles on F-actin polymerization and actin cytoskeleton organization. Results: The loss of hTid-1S expression was observed in lesional human psoriatic skin. Conclusion: The binding of hTid-1S with MK5 inhibits HSP27 phosphorylation and attenuates F-acti...

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Veröffentlicht in:	The Journal of biological chemistry 2012-07, Vol.287 (31), p.25954-25963
Hauptverfasser:	Choi, Ji Hye, Choi, Dae-Kyoung, Sohn, Kyung-Cheol, Kwak, Sang Su, Suk, Jinkyu, Lim, Jong-Soon, Shin, Incheol, Kim, Sung-Woo, Lee, Jeung-Hoon, Joe, Cheol O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actins - metabolism Case-Control Studies Cell Biology Cell Hypoxia Cell Migration Cell Movement Cell Proliferation Cytoskeleton Down-Regulation Epidermis F-actin Heat-Shock Proteins HeLa Cells HSP27 HSP27 Heat-Shock Proteins - metabolism HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism hTid-1 Humans Intracellular Signaling Peptides and Proteins - metabolism Keratinocytes Keratinocytes - metabolism Keratinocytes - physiology MK5 Molecular Chaperones p38 MAPK Phosphorylation Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Protein Multimerization Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - metabolism Psoriasis Psoriasis - metabolism Psoriasis - pathology Signal Transduction Skin - metabolism Skin - pathology
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