Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia
It remains unclear whether structural brain abnormalities in schizophrenia are caused by genetic and/or disease-related factors. Structural brain abnormalities have been found in nonpsychotic first-degree relatives of patients with schizophrenia, but results are inconclusive. This large magnetic res...
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| Veröffentlicht in: | Schizophrenia bulletin 2012-06, Vol.38 (4), p.814-825 |
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| creator | BOOS, Heleen B. M CAHN, Wiepke HAREN, Neeltje E. M. Van DERKS, Eske M BROUWER, Rachel M SCHNACK, Hugo G HULSHOFF POL, Hilleke E KAHN, René S |
| description | It remains unclear whether structural brain abnormalities in schizophrenia are caused by genetic and/or disease-related factors. Structural brain abnormalities have been found in nonpsychotic first-degree relatives of patients with schizophrenia, but results are inconclusive. This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements.
From 155 patients with schizophrenia, their 186 nonpsychotic siblings, and 122 healthy controls (including 25 sibling pairs), whole-brain scans were obtained. Segmentations of total brain, gray matter (GM), and white matter of the cerebrum, lateral and third ventricle, and cerebellum volumes were obtained. For each subject, measures of cortical thickness and GM density maps were estimated. Group differences in volumes, cortical thickness, and GM density were analyzed using Structural Equation Modeling, hence controlling for familial dependency of the data.
Patients with schizophrenia, but not their nonpsychotic siblings, showed volumetric differences, cortical thinning, and reduced GM density as compared with control subjects.
This study did not reveal structural brain abnormalities in nonpsychotic siblings of patients with schizophrenia compared with healthy control subjects using multiple imaging methods. Therefore, the structural brain abnormalities observed in patients with schizophrenia are for the largest part explained by disease-related factors. |
| doi_str_mv | 10.1093/schbul/sbq147 |
| format | Article |
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From 155 patients with schizophrenia, their 186 nonpsychotic siblings, and 122 healthy controls (including 25 sibling pairs), whole-brain scans were obtained. Segmentations of total brain, gray matter (GM), and white matter of the cerebrum, lateral and third ventricle, and cerebellum volumes were obtained. For each subject, measures of cortical thickness and GM density maps were estimated. Group differences in volumes, cortical thickness, and GM density were analyzed using Structural Equation Modeling, hence controlling for familial dependency of the data.
Patients with schizophrenia, but not their nonpsychotic siblings, showed volumetric differences, cortical thinning, and reduced GM density as compared with control subjects.
This study did not reveal structural brain abnormalities in nonpsychotic siblings of patients with schizophrenia compared with healthy control subjects using multiple imaging methods. Therefore, the structural brain abnormalities observed in patients with schizophrenia are for the largest part explained by disease-related factors.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sbq147</identifier><identifier>PMID: 21242319</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Brain - pathology ; Case-Control Studies ; Cerebral Cortex - pathology ; Cerebral Ventricles - pathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Organ Size ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - genetics ; Psychotic Disorders - pathology ; Regular ; Schizophrenia ; Schizophrenia - genetics ; Schizophrenia - pathology ; Siblings</subject><ispartof>Schizophrenia bulletin, 2012-06, Vol.38 (4), p.814-825</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2012. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-e49e7aa2735e9654d008d5a6cb3a58c653bf448e264ab456d8d2d7f2f0c5961e3</citedby><cites>FETCH-LOGICAL-c450t-e49e7aa2735e9654d008d5a6cb3a58c653bf448e264ab456d8d2d7f2f0c5961e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406520/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406520/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26176276$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21242319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOOS, Heleen B. M</creatorcontrib><creatorcontrib>CAHN, Wiepke</creatorcontrib><creatorcontrib>HAREN, Neeltje E. M. Van</creatorcontrib><creatorcontrib>DERKS, Eske M</creatorcontrib><creatorcontrib>BROUWER, Rachel M</creatorcontrib><creatorcontrib>SCHNACK, Hugo G</creatorcontrib><creatorcontrib>HULSHOFF POL, Hilleke E</creatorcontrib><creatorcontrib>KAHN, René S</creatorcontrib><title>Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>It remains unclear whether structural brain abnormalities in schizophrenia are caused by genetic and/or disease-related factors. Structural brain abnormalities have been found in nonpsychotic first-degree relatives of patients with schizophrenia, but results are inconclusive. This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements.
From 155 patients with schizophrenia, their 186 nonpsychotic siblings, and 122 healthy controls (including 25 sibling pairs), whole-brain scans were obtained. Segmentations of total brain, gray matter (GM), and white matter of the cerebrum, lateral and third ventricle, and cerebellum volumes were obtained. For each subject, measures of cortical thickness and GM density maps were estimated. Group differences in volumes, cortical thickness, and GM density were analyzed using Structural Equation Modeling, hence controlling for familial dependency of the data.
Patients with schizophrenia, but not their nonpsychotic siblings, showed volumetric differences, cortical thinning, and reduced GM density as compared with control subjects.
This study did not reveal structural brain abnormalities in nonpsychotic siblings of patients with schizophrenia compared with healthy control subjects using multiple imaging methods. Therefore, the structural brain abnormalities observed in patients with schizophrenia are for the largest part explained by disease-related factors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Ventricles - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - genetics</subject><subject>Psychotic Disorders - pathology</subject><subject>Regular</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - pathology</subject><subject>Siblings</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1P2zAYh60JNEq3464oFyQuof52cpkE1fiQgE1i047WG8dpjNK4tZNJ8NfjraWwGye_th_99Hv1IPSF4FOCSzaLpq3GbharNeHqA5oQxUVOFCZ7aIJFIXMlCT9AhzE-YEx4KelHdEAJ5ZSRcoLuLryBLjvr6-yy81UazwO4Pru1EMdgl7YfYpbu967qXL-ImW-yHzC4f--_3dBm96Z1T37VBts7-IT2G-ii_bw9p-jXxbef86v85vvl9fzsJjdc4CG3vLQKgCombCkFrzEuagHSVAxEYaRgVcN5YankUHEh66KmtWpog40oJbFsir5ucldjtbS1SXUCdHoV3BLCo_bg9P8_vWv1wv_RjGMpKE4BJ9uA4NejjYNeumhs10Fv_Rg14aRkssDiHShmqT5mkiQ036Am-BiDbXaNCNZ_demNLr3Rlfijt2vs6Bc_CTjeAhCTpyZAb1x85SRRkirJngE7RJ_4</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>BOOS, Heleen B. M</creator><creator>CAHN, Wiepke</creator><creator>HAREN, Neeltje E. M. Van</creator><creator>DERKS, Eske M</creator><creator>BROUWER, Rachel M</creator><creator>SCHNACK, Hugo G</creator><creator>HULSHOFF POL, Hilleke E</creator><creator>KAHN, René S</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20120601</creationdate><title>Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia</title><author>BOOS, Heleen B. M ; CAHN, Wiepke ; HAREN, Neeltje E. M. Van ; DERKS, Eske M ; BROUWER, Rachel M ; SCHNACK, Hugo G ; HULSHOFF POL, Hilleke E ; KAHN, René S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-e49e7aa2735e9654d008d5a6cb3a58c653bf448e264ab456d8d2d7f2f0c5961e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Case-Control Studies</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Ventricles - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic Disorders - genetics</topic><topic>Psychotic Disorders - pathology</topic><topic>Regular</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - pathology</topic><topic>Siblings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOOS, Heleen B. M</creatorcontrib><creatorcontrib>CAHN, Wiepke</creatorcontrib><creatorcontrib>HAREN, Neeltje E. M. Van</creatorcontrib><creatorcontrib>DERKS, Eske M</creatorcontrib><creatorcontrib>BROUWER, Rachel M</creatorcontrib><creatorcontrib>SCHNACK, Hugo G</creatorcontrib><creatorcontrib>HULSHOFF POL, Hilleke E</creatorcontrib><creatorcontrib>KAHN, René S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOOS, Heleen B. M</au><au>CAHN, Wiepke</au><au>HAREN, Neeltje E. M. Van</au><au>DERKS, Eske M</au><au>BROUWER, Rachel M</au><au>SCHNACK, Hugo G</au><au>HULSHOFF POL, Hilleke E</au><au>KAHN, René S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>38</volume><issue>4</issue><spage>814</spage><epage>825</epage><pages>814-825</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>It remains unclear whether structural brain abnormalities in schizophrenia are caused by genetic and/or disease-related factors. Structural brain abnormalities have been found in nonpsychotic first-degree relatives of patients with schizophrenia, but results are inconclusive. This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements.
From 155 patients with schizophrenia, their 186 nonpsychotic siblings, and 122 healthy controls (including 25 sibling pairs), whole-brain scans were obtained. Segmentations of total brain, gray matter (GM), and white matter of the cerebrum, lateral and third ventricle, and cerebellum volumes were obtained. For each subject, measures of cortical thickness and GM density maps were estimated. Group differences in volumes, cortical thickness, and GM density were analyzed using Structural Equation Modeling, hence controlling for familial dependency of the data.
Patients with schizophrenia, but not their nonpsychotic siblings, showed volumetric differences, cortical thinning, and reduced GM density as compared with control subjects.
This study did not reveal structural brain abnormalities in nonpsychotic siblings of patients with schizophrenia compared with healthy control subjects using multiple imaging methods. Therefore, the structural brain abnormalities observed in patients with schizophrenia are for the largest part explained by disease-related factors.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21242319</pmid><doi>10.1093/schbul/sbq147</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Schizophrenia bulletin, 2012-06, Vol.38 (4), p.814-825 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Brain - pathology Case-Control Studies Cerebral Cortex - pathology Cerebral Ventricles - pathology Female Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Male Medical sciences Middle Aged Organ Size Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - genetics Psychotic Disorders - pathology Regular Schizophrenia Schizophrenia - genetics Schizophrenia - pathology Siblings |
| title | Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia |
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